語系:
繁體中文
English
說明(常見問題)
圖資館首頁
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
作者:
Li, Zhitao.
面頁冊數:
310 p.
附註:
Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4944.
附註:
Supervisor: Michael C. Pirrung.
Contained By:
Dissertation Abstracts International64-10B.
標題:
Chemistry, Organic.
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3109014
ISBN:
0496565591
Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
Li, Zhitao.
Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
[electronic resource] - 310 p.
Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4944.
Thesis (Ph.D.)--Duke University, 2003.
Diabetes affects 5% of the U.S. population. Insulin is the most important drug in treating diabetes mellitus, however, it is not orally active. Demethylasterriquinone B1 (DAQ-B1) is a natural product that was reported to be insulin mimetic and have oral anti-diabetic activity. Dihydroxybisindolylbenzoquinone, the general structure of DAQ compounds, may be potentially a general structural class of growth factor mimetics. The goal of our research has been to study the total synthesis of DAQ-B1 and synthesis of its analogues for the purpose of studying the mechanism of DAQ-B1's activity and develop a combinatorial synthesis of DAQ libraries for screening of drug candidates with higher anti-diabetic activities.
ISBN: 0496565591Subjects--Topical Terms:
193634
Chemistry, Organic.
Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
LDR
:02754nmm _2200277 _450
001
162261
005
20051017073427.5
008
230606s2003 eng d
020
$a
0496565591
035
$a
00148762
035
$a
162261
040
$a
UnM
$c
UnM
100
0
$a
Li, Zhitao.
$3
227387
245
1 0
$a
Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
$h
[electronic resource]
300
$a
310 p.
500
$a
Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4944.
500
$a
Supervisor: Michael C. Pirrung.
502
$a
Thesis (Ph.D.)--Duke University, 2003.
520
#
$a
Diabetes affects 5% of the U.S. population. Insulin is the most important drug in treating diabetes mellitus, however, it is not orally active. Demethylasterriquinone B1 (DAQ-B1) is a natural product that was reported to be insulin mimetic and have oral anti-diabetic activity. Dihydroxybisindolylbenzoquinone, the general structure of DAQ compounds, may be potentially a general structural class of growth factor mimetics. The goal of our research has been to study the total synthesis of DAQ-B1 and synthesis of its analogues for the purpose of studying the mechanism of DAQ-B1's activity and develop a combinatorial synthesis of DAQ libraries for screening of drug candidates with higher anti-diabetic activities.
520
#
$a
Lewis acid-catalyzed reactions between monoindolylquinones and indoles were studied to introduce indoles to monoindolylquinones, which cannot be accomplished by Bronsted acid catalyst. High throughput combinatorial synthesis of dihydroxybisindolylbenzoquinones was established based on the Lewis acid-catalyzed reaction. A library of DAQ compounds was made via this high throughput method. These compounds will be subjected to bioactivity testing as mimetics of both insulin and other growth factors.
520
#
$a
The reaction between indoles and dichlorobenzoquinone was studied and an efficient acid catalyzed condensation reaction was developed as a method to synthesize indolylquinone, the key structure of DAQ-B1. A total synthesis of DAQ-B1 was accomplished based on this acid-catalyzed condensation reaction and a Stille coupling reaction. This acid-catalyzed condensation reaction was also used in the synthesis of compounds similar to DAQ-B1, such as dihydroxymonoindolylbenzoquinones and dihydroxyindolylnaphthoquinones.
590
$a
School code: 0066.
650
# 0
$a
Chemistry, Organic.
$3
193634
650
# 0
$a
Chemistry, Pharmaceutical.
$3
206042
710
0 #
$a
Duke University.
$3
226880
773
0 #
$g
64-10B.
$t
Dissertation Abstracts International
790
$a
0066
790
1 0
$a
Pirrung, Michael C.,
$e
advisor
791
$a
Ph.D.
792
$a
2003
856
4 0
$u
http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3109014
$z
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3109014
筆 0 讀者評論
全部
電子館藏
館藏
1 筆 • 頁數 1 •
1
條碼號
館藏地
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
000000000754
電子館藏
1圖書
學位論文
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
多媒體檔案
http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3109014
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼
登入