國立高雄大學圖資館 |

登入

回首頁

Quantitative studies of the Sonic hedgehog system in adult neural stem cells

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Quantitative studies of the Sonic hedgehog system in adult neural stem cells
作者:	Lai, Karen Wei-Sing.
面頁冊數:	120 p.
附註:	Chair: David V. Schaffer.
附註:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0885.
Contained By:	Dissertation Abstracts International65-02B.
標題:	Engineering, Chemical.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121564
ISBN:	0496689150

Quantitative studies of the Sonic hedgehog system in adult neural stem cells
Lai, Karen Wei-Sing.

Quantitative studies of the Sonic hedgehog system in adult neural stem cells [electronic resource] - 120 p.

Chair: David V. Schaffer.

Thesis (Ph.D.)--University of California, Berkeley, 2003.

Neural stem cells provide immense opportunities for the development of new therapies in treating neurodegenerative illnesses. However, the understanding of how stem cells develop and mature into functional neurons and glial cells that ultimately become incorporated into the complex network of the nervous system is a vast undertaking. In this research, we focus upon the identification and investigation of an important signal, Sonic hedgehog (Shh). We demonstrate that Shh, a crucial factor that controls a wide range of activities during the development of the nervous system, regulates proliferation of adult neural stem cells. In addition, using a "systems biology" approach, we describe a theoretical model to illustrate how the genetic regulatory properties of this signaling system contribute to the all-or-none proliferative response made by these cells. These properties include hysteresis and negative feedback to counteract noise produced by fluctuations in the amount of signaling factors that participate in the system. Finally, we report the results of several experiments that were performed in order to provide physical meaning to the predictions of the model. Our results collectively reveal that Shh plays an important role in the responses of adult neural stem cells. By understanding the mechanism of response imposed by the Shh network structure, we can begin to comprehend how to manipulate stem cell behavior.

ISBN: 0496689150Subjects--Topical Terms:

226989
Engineering, Chemical.

Quantitative studies of the Sonic hedgehog system in adult neural stem cells
LDR:02468nmm _2200289 _450 001 162421
005 20051017073444.5
008 230606s2003 eng d
020 $a 0496689150
035 $a 00148922
035 $a 162421
040 $a UnM $c UnM
100 0 $a Lai, Karen Wei-Sing. $3 227557
245 1 0 $a Quantitative studies of the Sonic hedgehog system in adult neural stem cells $h [electronic resource]
300 $a 120 p.
500 $a Chair: David V. Schaffer.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0885.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2003.
520 # $a Neural stem cells provide immense opportunities for the development of new therapies in treating neurodegenerative illnesses. However, the understanding of how stem cells develop and mature into functional neurons and glial cells that ultimately become incorporated into the complex network of the nervous system is a vast undertaking. In this research, we focus upon the identification and investigation of an important signal, Sonic hedgehog (Shh). We demonstrate that Shh, a crucial factor that controls a wide range of activities during the development of the nervous system, regulates proliferation of adult neural stem cells. In addition, using a "systems biology" approach, we describe a theoretical model to illustrate how the genetic regulatory properties of this signaling system contribute to the all-or-none proliferative response made by these cells. These properties include hysteresis and negative feedback to counteract noise produced by fluctuations in the amount of signaling factors that participate in the system. Finally, we report the results of several experiments that were performed in order to provide physical meaning to the predictions of the model. Our results collectively reveal that Shh plays an important role in the responses of adult neural stem cells. By understanding the mechanism of response imposed by the Shh network structure, we can begin to comprehend how to manipulate stem cell behavior.
590 $a School code: 0028.
650 # 0 $a Engineering, Chemical. $3 226989
650 # 0 $a Engineering, Biomedical. $3 227004
650 # 0 $a Biology, Neuroscience. $3 226972
690 $a 0317
690 $a 0541
690 $a 0542
710 0 # $a University of California, Berkeley. $3 212474
773 0 # $g 65-02B. $t Dissertation Abstracts International
790 $a 0028
790 1 0 $a Schaffer, David V., $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121564 $z http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121564