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The development of DNA-templated organic synthesis :Mimicking nature's effective molarity-based approach to controlling chemical reactivity

Record Type:	Electronic resources : Monograph/item
Title/Author:	The development of DNA-templated organic synthesis :
Reminder of title:	Mimicking nature's effective molarity-based approach to controlling chemical reactivity
Author:	Gartner, Zev Jordan.
Description:	136 p.
Notes:	Adviser: David R. Liu.
Notes:	Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2397.
Contained By:	Dissertation Abstracts International65-05B.
Subject:	Chemistry, Biochemistry.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131844
ISBN:	0496790846

The development of DNA-templated organic synthesis :Mimicking nature's effective molarity-based approach to controlling chemical reactivity
Gartner, Zev Jordan.

The development of DNA-templated organic synthesis :Mimicking nature's effective molarity-based approach to controlling chemical reactivity [electronic resource] - 136 p.

Adviser: David R. Liu.

Thesis (Ph.D.)--Harvard University, 2004.

Nature uses evolution to discover functional nucleic acids and proteins. In order to apply this powerful approach to other chemical structures, a method is needed to translate an amplifiable information carrier such as DNA into arbitrary chemical structures. We have developed DNA-templated organic synthesis (DTS) as such a method. DTS can sequence-specifically generate products unrelated in structure to the DNA backbone, can proceed efficiently without functional group adjacency, can mediate sequence-programmed multistep small-molecule synthesis, and can enable reaction pathways that cannot be realized using conventional synthetic strategies. These properties of DTS allowed us to perform the first translation, selection and amplification of a library of oligonucleotides encoding a library of entirely synthetic macrocyclic peptide fumamarides. The methods developed here enable synthetic molecules to benefit from powerful manipulations previously available only to biological macromolecules.

ISBN: 0496790846Subjects--Topical Terms:

226900
Chemistry, Biochemistry.

The development of DNA-templated organic synthesis :Mimicking nature's effective molarity-based approach to controlling chemical reactivity
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