語系:
繁體中文
English
說明(常見問題)
圖資館首頁
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Enantioselective synthesis of (+)-L-696,474 and (+)-cytochalasin B
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Enantioselective synthesis of (+)-L-696,474 and (+)-cytochalasin B
作者:
Haidle, Andrew Marc.
面頁冊數:
292 p.
附註:
Adviser: Andrew G. Myers.
附註:
Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2419.
Contained By:
Dissertation Abstracts International65-05B.
標題:
Chemistry, Organic.
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131858
ISBN:
0496790986
Enantioselective synthesis of (+)-L-696,474 and (+)-cytochalasin B
Haidle, Andrew Marc.
Enantioselective synthesis of (+)-L-696,474 and (+)-cytochalasin B
[electronic resource] - 292 p.
Adviser: Andrew G. Myers.
Thesis (Ph.D.)--Harvard University, 2004.
*Please refer to dissertation for diagrams.
ISBN: 0496790986Subjects--Topical Terms:
193634
Chemistry, Organic.
Enantioselective synthesis of (+)-L-696,474 and (+)-cytochalasin B
LDR
:02647nmm _2200277 _450
001
162689
005
20051017073512.5
008
230606s2004 eng d
020
$a
0496790986
035
$a
00149190
035
$a
162689
040
$a
UnM
$c
UnM
100
0
$a
Haidle, Andrew Marc.
$3
227833
245
1 0
$a
Enantioselective synthesis of (+)-L-696,474 and (+)-cytochalasin B
$h
[electronic resource]
300
$a
292 p.
500
$a
Adviser: Andrew G. Myers.
500
$a
Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2419.
502
$a
Thesis (Ph.D.)--Harvard University, 2004.
520
#
$a
*Please refer to dissertation for diagrams.
520
#
$a
The cytochalasins are structurally complex natural products with a broad range of apparently unrelated effects in different biological systems. Different members of the family have variously demonstrated inhibitory activity towards the formation of actin filaments, towards the functioning of HIV-1 protease, and towards the process of angiogenesis. The structural series is defined by a largely conserved, rigid bicyclic isoindolone core that is fused to a macrocyclic appendage. The latter structural component varies widely within the cytochalasins and appears to play an important role in the determination of biological activity. A convergent and enantioselective synthetic route to the cytochalasins was developed that allows for the late-stage introduction of macrocyclic appendages of different sizes and constitutions, as demonstrated by syntheses of the 14-membered macrolactone cytochalasin B (1, an inhibitor of the formation of actin filaments) and the 11-membered macrocarbocyclic cytochalasin L-696,474 (2, an inhibitor of HIV-1 protease) using common precursors. Synthetic transformations of note developed in the course of this work include the intramolecular Diels-Alder reaction of compound 84 to provide the endo adduct 83, the regioselective oxidation of the secondary amine 98 to furnish the imine 99, the transformation of the imine 99 into the lactam aldehyde 100 via the cyclic aminal 108 , the Horner-Wadsworth-Emmons ring closure of the ketophosphonate-aldehyde 81 to give the macrocarbocyclic ketone 137, and the magnesium sulfate-mediated opening of the epoxide group within 140 to afford 2.*
590
$a
School code: 0084.
650
# 0
$a
Chemistry, Organic.
$3
193634
690
$a
0490
710
0 #
$a
Harvard University.
$3
212445
773
0 #
$g
65-05B.
$t
Dissertation Abstracts International
790
$a
0084
790
1 0
$a
Myers, Andrew G.,
$e
advisor
791
$a
Ph.D.
792
$a
2004
856
4 0
$u
http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131858
$z
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131858
筆 0 讀者評論
全部
電子館藏
館藏
1 筆 • 頁數 1 •
1
條碼號
館藏地
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
000000001182
電子館藏
1圖書
學位論文
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
多媒體檔案
http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131858
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼
登入