國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The design and development of new tr...

Gamber, Gabriel Grant.

The design and development of new transition metal-catalyzed serial and multi-component cycloadditions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The design and development of new transition metal-catalyzed serial and multi-component cycloadditions.
作者:	Gamber, Gabriel Grant.
面頁冊數:	513 p.
附註:	Adviser: Paul A. Wender.
附註:	Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5726.
Contained By:	Dissertation Abstracts International65-11B.
標題:	Chemistry, Organic.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3153202
ISBN:	049613616X

The design and development of new transition metal-catalyzed serial and multi-component cycloadditions.
Gamber, Gabriel Grant.

The design and development of new transition metal-catalyzed serial and multi-component cycloadditions. - 513 p.

Adviser: Paul A. Wender.

Thesis (Ph.D.)--Stanford University, 2005.

Based on the chemoselectivity of the transition metal-catalyzed intermolecular [5+2] cycloaddition of vinylcyclopropanes for reaction with alkynes over alkenes, a serial [5+2]/[4+2] cycloaddition strategy was envisioned. This multi-component process affords complex polycyclic products with the formation of two new rings and up to four new stereocenters from three simple, readily available components. Significantly, higher yields are observed for a one-stage addition serial procedure than for the analogous two-stage addition procedure.

ISBN: 049613616XSubjects--Topical Terms:

193634
Chemistry, Organic.

The design and development of new transition metal-catalyzed serial and multi-component cycloadditions.
LDR:03652nmm _2200301 _450 001 167288
005 20061005085840.5
008 090528s2005 eng d
020 $a 049613616X
035 $a 00197904
040 $a UnM $c UnM
100 0 $a Gamber, Gabriel Grant. $3 237434
245 1 4 $a The design and development of new transition metal-catalyzed serial and multi-component cycloadditions.
300 $a 513 p.
500 $a Adviser: Paul A. Wender.
500 $a Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5726.
502 $a Thesis (Ph.D.)--Stanford University, 2005.
520 # $a Based on the chemoselectivity of the transition metal-catalyzed intermolecular [5+2] cycloaddition of vinylcyclopropanes for reaction with alkynes over alkenes, a serial [5+2]/[4+2] cycloaddition strategy was envisioned. This multi-component process affords complex polycyclic products with the formation of two new rings and up to four new stereocenters from three simple, readily available components. Significantly, higher yields are observed for a one-stage addition serial procedure than for the analogous two-stage addition procedure.
520 # $a During studies of the [5+2+1] cycloaddition, a fundamentally new [5+1+2+1] cycloaddition was identified. This four-component process affords hydroxyindanone products in good yields from vinylcyclopropanes, alkynes, and two equivalents of CO. A variety of terminal alkyl- and aryl- alkynes and substituted vinylcyclopropanes are effective in the reaction, leading to predictably substituted indanone derivatives. The reaction can also be carried out bidirectionally, with the formation of ten carbon-carbon bonds from seven components in a single operation.
520 # $a The capture of intermediates of the transition metal-catalyzed [4+2] cycloaddition of dienynes has led to the first example of a transition metal-catalyzed [4+2+1] cycloaddition, as well as a novel variation of the Pauson-Khand reaction. The dienyl Pauson-Khand reaction produces alkenylcyclopentenones in good to excellent yields and excellent diastereoselectivities. Significantly, control studies indicate that the diene facilitates the [2+2+1] cycloaddition relative to the analogous reactions with simple alkenes.
520 # $a The capture of intermediates of transition metal-catalyzed [ m+n] cycloadditions with one or more additional components is an attractive strategy to produce new multi-component [ m+n+o...(+x)] cycloadditions. Based on capture of intermediates of a [5+2] cycloaddition, a fundamentally new [5+2+1] cycloaddition of vinylcyclopropanes, alkynes, and CO has been developed. This three-component cycloaddition proceeds in good to excellent yields and with high or complete regioselectivity to give cyclooctendione products, as well as bicyclo[3.3.0]octenone products that result from a serial in situ transannular closure process.
520 # $a The continued progress of organic synthesis depends heavily on the design and development of new strategies and strategic reactions that allow for the synthesis of complex, and therefore information rich, targets in a step-economical, if not ideal, fashion from readily available starting materials. Serial and multi-component cycloadditions provide a powerful means to achieve this goal.
590 $a School code: 0212.
650 # 0 $a Chemistry, Organic. $3 193634
690 $a 0490
710 0 # $a Stanford University. $3 212607
773 0 # $g 65-11B. $t Dissertation Abstracts International
790 $a 0212
790 1 0 $a Wender, Paul A., $e advisor
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://libsw.nuk.edu.tw:81/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3153202 $z http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3153202