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Investigations of novel ascidian met...

Long, Charli Marie.

Investigations of novel ascidian metabolites.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigations of novel ascidian metabolites.
作者:	Long, Charli Marie.
面頁冊數:	281 p.
附註:	Adviser: Madeleine M. Joullie.
附註:	Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3803.
Contained By:	Dissertation Abstracts International67-07B.
標題:	Chemistry, Organic.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3225496
ISBN:	9780542799716

Investigations of novel ascidian metabolites.
Long, Charli Marie.

Investigations of novel ascidian metabolites. - 281 p.

Adviser: Madeleine M. Joullie.

Thesis (Ph.D.)--University of Pennsylvania, 2006.

Structure-activity relationship studies performed with various didemnin analogues have demonstrated that the linear side chain portion of the molecule is vital to its biological potency. Three tamandarin analogues were prepared which consisted of the macrocycle of the natural product tamandarin B and side chains found in extremely potent didemnin compounds. The macrocycle was prepared using a revised approach with a new site of macrolactamization. The final analogues will all be subjected to biological activity screening.

ISBN: 9780542799716Subjects--Topical Terms:

193634
Chemistry, Organic.

Investigations of novel ascidian metabolites.
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100 0 $a Long, Charli Marie. $3 264199
245 1 0 $a Investigations of novel ascidian metabolites.
300 $a 281 p.
500 $a Adviser: Madeleine M. Joullie.
500 $a Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3803.
502 $a Thesis (Ph.D.)--University of Pennsylvania, 2006.
520 # $a Structure-activity relationship studies performed with various didemnin analogues have demonstrated that the linear side chain portion of the molecule is vital to its biological potency. Three tamandarin analogues were prepared which consisted of the macrocycle of the natural product tamandarin B and side chains found in extremely potent didemnin compounds. The macrocycle was prepared using a revised approach with a new site of macrolactamization. The final analogues will all be subjected to biological activity screening.
520 # $a The tamandarins are a class of naturally occurring cyclic depsipeptides isolated from a Brazilian ascidian. They are structurally similar to a more widely studied class of depsipeptides known as the didemnins. Both the didemnins and the tamandarins are of interest because of their wide range of impressive biological activity and their potential use as a drug therapy for many different diseases. Although numerous synthetic studies have identified structural elements that are critical in the biological activity profile, the identification of a receptor protein that could explain the variety of biological properties remains elusive. In an effort to identify a receptor protein, a synthetic analogue, [lys3] tamandarin B, was prepared. This analogue was designed for use in affinity chromatography studies and its synthetic preparation is discussed in detail. As the tamandarins are accepted as synthetic mimics of the didemnins, it is hoped that the future affinity studies conducted with this analogue will identify molecular targets of both the tamandarins and didemnins.
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