語系:
繁體中文
English
說明(常見問題)
圖資館首頁
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Genome-wide reconstructions of the e...
~
Harvard University.
Genome-wide reconstructions of the evolution of genes and regulatory elements in Ascomycota fungi.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Genome-wide reconstructions of the evolution of genes and regulatory elements in Ascomycota fungi.
作者:
Wapinski, Ilan N.
面頁冊數:
138 p.
附註:
Advisers: Avi Pfeffer; Aviv Regev.
附註:
Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: .
Contained By:
Dissertation Abstracts International69-10B.
標題:
Biology, General.
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334816
ISBN:
9780549882510
Genome-wide reconstructions of the evolution of genes and regulatory elements in Ascomycota fungi.
Wapinski, Ilan N.
Genome-wide reconstructions of the evolution of genes and regulatory elements in Ascomycota fungi.
- 138 p.
Advisers: Avi Pfeffer; Aviv Regev.
Thesis (Ph.D.)--Harvard University, 2008.
Comparative genomics relies heavily on determining the corresponding features between organisms. An accurate and comprehensive cross-species mapping is essential for extracting meaningful insights by comparing genome sequences. For example, tracing the exact evolutionary history of each gene in a panel of species allows us investigate the consequences of gene duplication and loss events; two key sources of phenotypic innovation.
ISBN: 9780549882510Subjects--Topical Terms:
226898
Biology, General.
Genome-wide reconstructions of the evolution of genes and regulatory elements in Ascomycota fungi.
LDR
:03734nam _2200325 _450
001
206972
005
20090413130356.5
008
090730s2008 ||||||||||||||||| ||eng d
020
$a
9780549882510
035
$a
00372184
040
$a
UMI
$c
UMI
100
$a
Wapinski, Ilan N.
$3
321910
245
1 0
$a
Genome-wide reconstructions of the evolution of genes and regulatory elements in Ascomycota fungi.
300
$a
138 p.
500
$a
Advisers: Avi Pfeffer; Aviv Regev.
500
$a
Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: .
502
$a
Thesis (Ph.D.)--Harvard University, 2008.
520
$a
Comparative genomics relies heavily on determining the corresponding features between organisms. An accurate and comprehensive cross-species mapping is essential for extracting meaningful insights by comparing genome sequences. For example, tracing the exact evolutionary history of each gene in a panel of species allows us investigate the consequences of gene duplication and loss events; two key sources of phenotypic innovation.
520
$a
In this thesis, we propose computational methods for advancing these biological questions. First, we introduce a new framework for identifying orthologous genes across a phylogeny, capturing exactly when genes were duplicated and lost. This general framework integrates various sources of evidence into a robust and scalable approach for recovering accurate gene histories from the genome annotations of extant species. We apply this framework across a panel of sequenced Ascomycota fungi genomes, allowing us to pursue new insights into the evolutionary signatures of gene duplication and loss in these species. We determine the functional principles that govern these processes, and how the forces of selection can operate distinctly between genes with different functional roles and between duplication events of different scales. Lastly, we extend this framework towards tracing the evolution of cis-regulatory elements. After building comprehensive species-specific motif catalogs, we map the corresponding elements between genomes, allowing us to glimpse into how transcription factor binding sites can be reshaped across evolution.
520
$a
The recent availability of fully sequenced genomes from multiple related organisms has allowed researchers to investigate many long-standing questions in biology using the emerging paradigm of comparative genomics. These include: how phenotypic novelty arises through sequence divergence, how genome organization is restructured in drastic and subtle ways, and how the rich repertoire of interactions that constitute gene regulatory networks exhibit tremendous plasticity.
520
$a
These studies thoroughly embrace the potential of comparative genomics. Sequencing and annotating genomes were the initial steps towards harnessing evolution to garner new discoveries about cellular behavior. Our precise mapping of shared ancestral relations between the components of each genome realizes this promise of comparative genomics. We study how the resulting catalog of gene phylogenies can reveal meaningful insights into the evolutionary constraints that govern them. In addition, by generating an encyclopedic library of functional cis-elements, we establish the foundations for future studies of regulatory network evolution.
590
$a
School code: 0084.
650
$a
Biology, General.
$3
226898
650
$a
Biology, Bioinformatics.
$3
264207
650
$a
Computer Science.
$3
212513
690
$a
0306
690
$a
0715
690
$a
0984
710
$a
Harvard University.
$3
212445
773
0
$g
69-10B.
$t
Dissertation Abstracts International
790
$a
0084
790
1 0
$a
Pfeffer, Avi,
$e
advisor
790
1 0
$a
Regev, Aviv,
$e
advisor
791
$a
Ph.D.
792
$a
2008
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334816
$z
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334816
筆 0 讀者評論
全部
電子館藏
館藏
1 筆 • 頁數 1 •
1
條碼號
館藏地
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
000000024403
電子館藏
1圖書
電子書
TH
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
多媒體檔案
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334816
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼
登入