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綠色化學製程於莪朮萃取物之功能性質研究 = Functional Pro...

何桂鴻

綠色化學製程於莪朮萃取物之功能性質研究 = Functional Properties of Extracts from Curcuma zedoariavia Green Chemical Processes

紀錄類型:	書目-語言資料,印刷品 : 單行本
並列題名:	Functional Properties of Extracts from Curcuma zedoariavia Green Chemical Processes
作者:	何桂鴻,
其他團體作者:	國立高雄大學
出版地:	[高雄市]
出版者:	撰者;
出版年:	2009[民98]
面頁冊數:	126面圖、表 : 30公分;
標題:	綠色化學製程
標題:	Curcuma zedoaria
電子資源:	http://handle.ncl.edu.tw/11296/ndltd/00968644844404278543
附註:	指導教授：吳永昌
附註:	參考書目：面
摘要註:	超臨界二氧化碳和離子液體被視為“綠色”溶劑，目前活躍於化學反應和分離的研究領域，二氧化碳最常被選擇做為超臨界萃取的溶劑，是因為其具有適切的臨界常數(臨界壓力為73 atm和臨界溫度為31 oC)、化學不活潑以及低成本的特性。過去十年，二氧化碳超臨界流體已被廣泛使用在金屬的溶解與萃取。現今，天然物化學結合超臨界萃取的研究已被廣泛使用。薑科植物，莪朮 (俗名為片薑黃) 為多年生植物，主要分佈在亞洲國家(中國、越南、印度和日本。莪朮的根莖部為一種東方藥材，用於健胃、治療血液淤塞、保肝和催經。使用二氧化碳超臨界流體當作溶劑來萃取莪朮粉末的活性成分，探討不同萃取條件的動力學而建立出一套高效能的萃取方法。研究不同萃取壓力在不同條件下的影響，萃取物的產率以及其生物活性被進一步分析。8個條件下所得的粗萃取物(ZR-1至ZR-8)進行細胞毒殺、抗發炎以及抗血小板凝集活性的測試。活性的萃取層，ZR-1，藉由管柱層析法共取得6個倍半萜，分別為curzerenone (1)、curdione (2)、zedorone (3)、curcumenone (4)、procurcumenone (5)以及zedoarondiol (6)，其化學結構由核磁共振光譜及質譜儀進行鑑定。化合物的生物活性試驗正於進行中。 The use of supercritical CO2 (sc-CO2) and ionic liquids (ILs) as “green” solvents for chemical reactions and separations is currently an active research area. Carbon dioxide is often chosen for supercritical fluid extraction (SFE) due to its moderate critical constants (Pc=73 atm and Tc=31 oC), chemical inertness, and low cost. The use of sc-CO2 as a solvent for dissolution and extraction of metal species has been extensively studied during the last decade. Nowadays, nature product research combining supercritical fluid extraction (SFE) is in widespread use. The Zingberaceae plant Curcuma zedoaria ROSCOE (the common name, Zedoary) is a perennial plant mainly distributed in Asian countries, including China, Vienam, India, and Japan . The rhizome, Zedoaria Rhizoma (ZR), has been used for treatment of stomachic, blood stagnation, hepatoprotection, and promoting menstruation as an oriental medicine. The kinetics of the supercritical fluid extraction of bioactive compounds from the powders of ZR using CO2 as solvent were studied in order to establish an efficient method for extraction. The influence of time of extraction at different conditions was investigated. The extraction yields and the bioactivity levels of the extracts were also analysed. The eight extracts (ZR-1 to 8) were prepared and investigated on their cytotoxic, anti-inflammatory and antiplatelet aggregation activities. The active extract, ZR-1, was separated by column chromatography and TLC to obtaining four zederone (1), curcumenone (2), and procurcumenone (3), and their structures and relative stereochemistry were determined by NMR, MS, etc. Bioactivities of isolates are currently under investigation.

綠色化學製程於莪朮萃取物之功能性質研究 = Functional Properties of Extracts from Curcuma zedoariavia Green Chemical Processes
何, 桂鴻

綠色化學製程於莪朮萃取物之功能性質研究 = Functional Properties of Extracts from Curcuma zedoariavia Green Chemical Processes / 何桂鴻撰 - [高雄市] : 撰者, 2009[民98]. - 126面 ; 圖、表 ; 30公分.
指導教授：吳永昌參考書目：面.
綠色化學製程Curcuma zedoaria

綠色化學製程於莪朮萃取物之功能性質研究 = Functional Properties of Extracts from Curcuma zedoariavia Green Chemical Processes
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