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微脂粒與界面活性劑交互作用對於孔洞材料合成之影響 = Study on ...

國立高雄大學生物科技研究所

微脂粒與界面活性劑交互作用對於孔洞材料合成之影響 = Study on the interaction between liposome and surfactant during self assembly of mesoporous silica

紀錄類型:	書目-語言資料,印刷品 : 單行本
並列題名:	Study on the interaction between liposome and surfactant during self assembly of mesoporous silica
作者:	葛彥霆,
其他團體作者:	國立高雄大學
出版地:	[高雄市]
出版者:	撰者;
出版年:	2010[民99]
面頁冊數:	88面圖，表 : 30公分;
標題:	MCM-41
標題:	MCM-41
電子資源:	http://handle.ncl.edu.tw/11296/ndltd/52676337737775235694
摘要註:	介孔矽氧化物結構與微胞構造具有密切關係，改變界面活性劑分子的濃度，微胞的型態隨著改變，自組裝形成介孔矽氧化物結構隨之不同。當CTAB界面活性劑的濃度超過臨界微胞濃度CMC1、CMC2時，二氧化矽SiO2便會組裝產生六角型柱狀的結構，形成MCM-41結構。微脂粒和微胞之交互作用，已經在文獻中普遍的被探討。增加界面活性劑分子濃度，超越CMC1時，微脂粒結構體隨之破壞，生成混合微胞。本文主要的重點在於探討微脂粒和微胞之間的交互作用，以之產生混合微胞共模板，對於所合成之孔洞材料結構之影響，藉以建立不同磷脂質共模板自組裝介孔材料結構之預測模型。吾人選用四種結構不同的磷脂質，分別為短鏈雙尾DHPC及長鏈單尾磷脂質DDPC，長鏈雙尾飽和磷脂質DMPC與長鏈雙尾不飽和磷脂質lecithin，結果顯示，在相同混合比例下，四種磷脂質與CTAB共模板皆可導引SiO2自組裝形成MCM-41介孔結構。其中，DHPC及DDPC所形成之介孔結構之熱穩定性不佳，其XRD呈現之規則形構造經過鍛燒後皆消失。相對的，DMPC與lecithin磷脂質共模板所導引組裝之介孔結構具有較好之熱穩定性。針對DMPC與lecithin磷脂質，在固定CTAB濃度下，微脂粒濃度對於MCM-41結構及熱穩定性並無明顯影響，未有明顯擴孔行為，lecithin系統之壁厚並無改變，但DMPC系統壁厚明顯的增厚，表面積明顯隨之下降。在固定磷脂質濃度下，lecithin系統之熱穩定性明顯變弱，DMPC系統產生之六角柱狀結構材料之規則性及熱穩定性則隨著CTAB濃度降低而逐漸減弱，伴隨著孔徑增加及壁厚變厚。以濁度試驗測試混合微胞的生成，實驗結果顯示，微脂粒在吾人所選用之CTAB濃度均呈破壞之現象，而進一步對照加入矽源後之XRD結果，可間接反映微脂粒破壞後所生成之混合微胞之結構，意即當CTAB濃度突破CMC1而破壞微脂粒時，所形成之混合微胞不具六角柱狀堆疊特性，而後進一步突破CMC2時混合微胞開始具有六角柱狀之結構特性，但結構之穩定性及物理性質將受到磷脂質之影響。 Micelle is used to be an organic template to direct the self-assembly of mesoporous materials and it often has varied morphology while detergent concentration changes. According to above, there are several kinds of mesoporous material formed at different concentration of detergent. While detergent concentration is in excess of critical micelle concentration 1 and 2(CMC1 andCMC2), the hexagonal phase forms and the addition of silicon source can lead to the formation of a well-known mesoporous material, MCM-41.Vesicle to micelle transition has been widely studied in lectures. With increasing the concentration of detergent, lipid vesicle (also called liposome )will be solubilized among CMC and mixed micelle forms at the same time. In this study, we utilize mixed micelle formed from mixing different kinds of phospholipid with CTAB to synthesize mesoporous material. We also study the concentration effect of co-surfactant on the mesoporous materials. In addition, we try to build a prediction model which can describe the effect of co-surfactant with different phospholipid. There are four kinds of phospholipd we use in this study to investigate the structure effect in the co-surfactant system, such as DHPC(short and double tail), DDPC(long and single chain), DMPC and lecithin(both of them are long and double chain, but former is saturated phospholipid, the other is unsaturated). XRD results show that although structure of phospholipids are different, they can mix with CTAB to be a template and to form MCM-41 at the same mixing ratio. But, after calcination, mesoporous structures formed from DHPC and DDPC co-surfactant show a poor thermalstability. In contrast to DHPC and DDPC, materials of DMPC and lecithin co-surfactant shows a better thermalstability.To compare lecithin and DMPC co-surfactant system, we set two conditions to identify the concentration effect. First is to make liposome/SiO2 as a constant and change the concentration of CTAB. Second is to make CTAB/SiO2 as a constant and change the concentration of liposome. In first condition, liposome will be solubilized with increasing concentration of CTAB and will form hexagonal phase at high concentration of CTAB. In this condition, some property of MCM-41 will be seriously affected at low ratio of CTAB/phospholipid, like existence of hexagonal phase、thermalstability of structure、 pore size、 surface area and so on. There is a different result in second condition. Materials maintain hexagonal phase no matter how concentration of liposome changes and pore size alter unobviously. But, wall thickness will increase in DMPC co-surfactant system. In contrast to DMPC, wall thickness has no apparent difference in lecithin co-surfactant system. In turbidity test, results show that mixed micelle formed while CTAB/phospholipid ratio increases. Addition of silicon source can identify the structure of mixed micelle. It means although liposome has been solubilized by CTAB, the structure of mixed micelle may not be hexagonal because concentration is not in excess of CMC2 and XRD shows that mesoporous structure is amorphous.

微脂粒與界面活性劑交互作用對於孔洞材料合成之影響 = Study on the interaction between liposome and surfactant during self assembly of mesoporous silica
葛, 彥霆

微脂粒與界面活性劑交互作用對於孔洞材料合成之影響 = Study on the interaction between liposome and surfactant during self assembly of mesoporous silica / 葛彥霆撰 - [高雄市] : 撰者, 2010[民99]. - 88面 ; 圖，表 ; 30公分.
參考書目：面82-88.
MCM-41MCM-41

微脂粒與界面活性劑交互作用對於孔洞材料合成之影響 = Study on the interaction between liposome and surfactant during self assembly of mesoporous silica
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