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A pharmacology primertheory, applica...

Kenakin, Terrence P.

A pharmacology primertheory, applications, and methods /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A pharmacology primerTerry P. Kenakin.
其他題名:	theory, applications, and methods /
作者:	Kenakin, Terrence P.
出版者:	Amsterdam ;Academic Press/Elsevier,c2009.
面頁冊數:	xix, 389 p. :ill. (some col.) ;29 cm.
標題:	Pharmacology, Experimental.
電子資源:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123745859

A pharmacology primertheory, applications, and methods /
Kenakin, Terrence P.

A pharmacology primertheory, applications, and methods /[electronic resource] :Terry P. Kenakin. - 3rd ed. - Amsterdam ;Academic Press/Elsevier,c2009. - xix, 389 p. :ill. (some col.) ;29 cm.

Includes bibliographical references and index.

What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.

This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments. The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles. Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2009.

Mode of access: World Wide Web.

ISBN: 9780123745859

Source: 158273:158442Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

274313
Pharmacology, Experimental.
Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RM301.25 / .K46 2009

Dewey Class. No.: 615/.7

National Library of Medicine Call No.: QV 38 / K33pg 2009

A pharmacology primertheory, applications, and methods /
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245 1 2 $a A pharmacology primer $h [electronic resource] : $b theory, applications, and methods / $c Terry P. Kenakin.
250 $a 3rd ed.
260 $a Amsterdam ; $a Boston : $b Academic Press/Elsevier, $c c2009.
300 $a xix, 389 p. : $b ill. (some col.) ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
520 $a This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments. The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles. Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2009. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Apr. 10, 2009). $n Access may be restricted to users at subscribing institutions.
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650 2 2 $a Dose-Response Relationship, Drug. $3 229701
650 2 2 $a Pharmacology $x methods. $3 267177
655 7 $a Electronic books. $2 local. $3 214472
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994 $a C0 $b TEF