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Generation and Function of CD8 T Cel...

Cush, Stephanie S.

Generation and Function of CD8 T Cell Memory to gamma-Herpesviral Infection.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Generation and Function of CD8 T Cell Memory to gamma-Herpesviral Infection.
作者:	Cush, Stephanie S.
面頁冊數:	176 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-03, Section: B, page: 1399.
附註:	Adviser: Emilio Flano.
Contained By:	Dissertation Abstracts International72-03B.
標題:	Biology, Virology.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3441389
ISBN:	9781124442761

Generation and Function of CD8 T Cell Memory to gamma-Herpesviral Infection.
Cush, Stephanie S.

Generation and Function of CD8 T Cell Memory to gamma-Herpesviral Infection. - 176 p.

Source: Dissertation Abstracts International, Volume: 72-03, Section: B, page: 1399.

Thesis (Ph.D.)--The Ohio State University, 2011.

>gamma-herpesviruses are a worldwide health concern, and result in a lifelong persistent infection that is associated with some degree of immune control preventing the virus from reactivating and causing disease. However, if this immune control is compromised, gamma-herpesviruses can reactivate and cause a variety of tumors in the host. Thus, there is a great need to increase our understanding of the immune response to this family of oncogenic viruses.

ISBN: 9781124442761Subjects--Topical Terms:

264226
Biology, Virology.

Generation and Function of CD8 T Cell Memory to gamma-Herpesviral Infection.
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245 1 0 $a Generation and Function of CD8 T Cell Memory to gamma-Herpesviral Infection.
300 $a 176 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-03, Section: B, page: 1399.
500 $a Adviser: Emilio Flano.
502 $a Thesis (Ph.D.)--The Ohio State University, 2011.
520 $a >gamma-herpesviruses are a worldwide health concern, and result in a lifelong persistent infection that is associated with some degree of immune control preventing the virus from reactivating and causing disease. However, if this immune control is compromised, gamma-herpesviruses can reactivate and cause a variety of tumors in the host. Thus, there is a great need to increase our understanding of the immune response to this family of oncogenic viruses.
520 $a CD8 T cells have been shown to be critical for viral control. The generation, maintenance, and function of CD8 T cell memory during persistent viral infections is poorly understood. The overall objective of my dissertation is to gain an in depth understanding of CD8 T cell memory generation, maintenance, and function during low load persistent viral infections. We are using a well-established murine model of gamma-herpes viral infection, murine gamma herpesvirus 68, or gammaHV68, to study the in vivo effects of a low load persistent infection on the generation and function of memory CD8 T cells. We determined that virus specific memory CD8 T cells are generated and maintained long term during gammaHV68 persistence through a variety of phenotypic and functional assays. We found that true bona fide memory CD8 T cells are fully functional during gammaHV68 latency, which is contrary to other chronic viral infections characterized by high antigenic load. We discovered that the gammaHV68 specific memory CD8 T cells are capable of surviving in a naive mouse after adoptive transfer and subsequently proliferating homeostatically in response to cytokines. Additionally, the adoptively transferred memory CD8 T cells have the ability to protect against secondary infection with gammaHV68. We found heterogeneous virus-specific CD8 T cell memory populations during gammaHV68 latency, and demonstrated that the terminally differentiated CD8 T cell memory is also equally as functional as the central memory CD8 T cell memory.
520 $a The current two dominating principles in the field of CD8 T cell memory are: 1) acute infection followed by viral clearance and stable memory formation and 2) persistent infection where there is no viral clearance which leads to T cell dysfunction. My data has contributed to the field of immunology by demonstrating that there is an additional option for how CD8 T cells function during persistent viral infections, where viral persistence does not always lead to memory CD8 T cell dysfunction.
520 $a Our objective is to gain critical knowledge about CD8 T cell memory to elucidate the possible mechanisms of CD8 T cell function and dysfunction during gammaHV68 infection. The in vivo model provides relevant information for how memory is generated and maintained in the host, and hopes to offer insights to new therapies and prevention strategies, which is important for many diseases afflicting the human population.
590 $a School code: 0168.
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650 4 $a Health Sciences, Immunology. $3 226966
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710 2 $a The Ohio State University. $b Integrated Biomedical Science Graduate Program. $3 530965
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791 $a Ph.D.
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