國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Negative regulation of regulatory T ...

Centuori, Sara.

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
作者:	Centuori, Sara.
面頁冊數:	90 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
附註:	Advisers: Nicolas Larmonier; Emmanuel Katsanis.
Contained By:	Dissertation Abstracts International72-07B.
標題:	Health Sciences, Immunology.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3452966
ISBN:	9781124608075

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
Centuori, Sara.

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer. - 90 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--The University of Arizona, 2011.

Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the immunosuppressive networks that contribute to tumor immune evasion. The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-regulation between MDSC and Treg remain incompletely defined. The current work evaluates the influence of MDSC, expanded in two mouse cancer models, on immunosuppressive Treg. We demonstrate that tumor-induced MDSC endowed with the potential of suppressing conventional T lymphocytes surprisingly impair TGF-beta1-mediated generation of induced Treg (iTreg) from naive CD4+ T lymphocytes. Suppression of iTreg generation by MDSC occurs early in the differentiation process, and is cell contact dependent. This inhibition of FoxP3-expressing T lymphocyte differentiation by MDSC does not depend on arginase 1, cystine/cysteine depletion, iNOS/NO, or PD-1/PD-L1 signaling. These findings therefore indicate that MDSC from tumor-bearing hosts have the heretofore unreported ability to restrict some immunosuppressive Treg subpopulations.

ISBN: 9781124608075Subjects--Topical Terms:

226966
Health Sciences, Immunology.

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
LDR:02277nmm 2200337 4500 001 309708
005 20111105132451.5
008 111212s2011 ||||||||||||||||| ||eng d
020 $a 9781124608075
035 $a (UMI)AAI3452966
035 $a AAI3452966
040 $a UMI $c UMI
100 1 $a Centuori, Sara. $3 531038
245 1 0 $a Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
300 $a 90 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
500 $a Advisers: Nicolas Larmonier; Emmanuel Katsanis.
502 $a Thesis (Ph.D.)--The University of Arizona, 2011.
520 $a Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the immunosuppressive networks that contribute to tumor immune evasion. The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-regulation between MDSC and Treg remain incompletely defined. The current work evaluates the influence of MDSC, expanded in two mouse cancer models, on immunosuppressive Treg. We demonstrate that tumor-induced MDSC endowed with the potential of suppressing conventional T lymphocytes surprisingly impair TGF-beta1-mediated generation of induced Treg (iTreg) from naive CD4+ T lymphocytes. Suppression of iTreg generation by MDSC occurs early in the differentiation process, and is cell contact dependent. This inhibition of FoxP3-expressing T lymphocyte differentiation by MDSC does not depend on arginase 1, cystine/cysteine depletion, iNOS/NO, or PD-1/PD-L1 signaling. These findings therefore indicate that MDSC from tumor-bearing hosts have the heretofore unreported ability to restrict some immunosuppressive Treg subpopulations.
590 $a School code: 0009.
650 4 $a Health Sciences, Immunology. $3 226966
650 4 $a Health Sciences, Oncology. $3 226907
690 $a 0982
690 $a 0992
710 2 $a The University of Arizona. $b Cancer Biology. $3 531039
773 0 $t Dissertation Abstracts International $g 72-07B.
790 1 0 $a Larmonier, Nicolas, $e advisor
790 1 0 $a Katsanis, Emmanuel, $e advisor
790 1 0 $a Bowden, Tim $e committee member
790 1 0 $a Briehl, Margaret $e committee member
790 1 0 $a Doetschman, Tom $e committee member
790 1 0 $a Lybarger, Lonnie $e committee member
790 $a 0009
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3452966