國立高雄大學圖資館 |

利用聚雙性分子改質不織布及其抗沾黏效果之評估 = Applications of polyzwitterions to modify nonwovens and their assessment of anti-fouling properties

紀錄類型:	書目-語言資料,印刷品 : 單行本
並列題名:	Applications of polyzwitterions to modify nonwovens and their assessment of anti-fouling properties
作者:	徐千祐,
其他團體作者:	國立高雄大學
出版地:	[高雄市]
出版者:	撰者;
出版年:	2012[民101]
面頁冊數:	87面圖，表格 : 30公分;
標題:	不織布
標題:	non-woven
電子資源:	http://handle.ncl.edu.tw/11296/ndltd/73545212212465860357
附註:	106年10月31日公開
附註:	參考書目：面71-74
摘要註:	本研究主要是使用多巴胺作為偶合劑，將不織布接上聚雙性分子作為生物功能之親水改質劑；並以針對其親水性質及血液相容性作探討。本研究分為二部份:不織布多巴胺改質、並分別接枝磷酸膽鹼及聚甜菜鹼作為不織布親水改質劑。不織布多巴胺改質部份是先以氧電漿處理不織布，並將不織布是浸入含多巴氨之磷酸緩衝溶液；藉由多巴胺發生氧化反應產生自動聚合反應(auto-polymerization)，將聚多巴胺接枝在不織布上。第一種親水改質劑是以卵磷脂經由鹼水解及氧化合成乙二醛磷酸膽鹼(phosphocholine glycoaldehyde )，並經由紅外光光譜及核磁共振鑑定其結構；接下來藉由修飾後的不織布與帶有乙二醛磷酸膽鹼在酸催化下形成希夫氏鹼鍵結。第二種親水改質劑是利用氧化還原聚合的方法，將甜菜鹼單體聚合並接枝在褐藻酸；使用氧化的褐藻酸與修飾後的不織布不織布，以相同方式接枝至不織布上。使用紅外光光譜鑑定不織布化學組成，並經由全血測試其血液相容性。 We used dopamine as a coupling agent to link bioactive and hydrophilic zwitterionic molecules onto nonwoven surfaces in order to assess the hydrophilicity, blood compatibility of modified nonwovens. Two zwitterionic functional molecules were introduced to graft nonwoven surfaces: phosphorylcholine (PC) and sulfobutaine (SB). Prime nonwovens were activated via oxygen plasma and then immersed into dopamine aqueous solution for a certain period. Oxidation of dopamine molecules induced auto-polymerization to form polydopamine coatings on nonwovens. Evaluation of ATR-FTIR of nonwovens before and after treatment was carried out to ensure the modification process. For the synthesis of zwitterionic molecules, phospholipid was basically hydrolyzed to remove its long aliphatic chains, and then oxidized to aldehyde group at the end of the structure. The aldehyde group was able to link with the amine group of dopamine-modified nonwoven via schiff base reaction. The other synthesis based on the graft copolymerization of sulfobetaine methacrylate (SBMA) on alginate was performed and also leave a convenient aldehyde group on the broken side chain of the alginate. The aldehyde group was then reacted with dopamine-modified nonwoven surface. All the synthesis of modifiers were characterized by NMR and IR, and also the surface changes of modified nonwovens were recognized via ATR-FTIR, contact angle meter, ESCA, and EDX. In the blood compatibility measurement, the modified nonwovens were observed via optical microscope and SEM to check their suppression of platelet adhesion after contacting with human whole blood for a certain time.

利用聚雙性分子改質不織布及其抗沾黏效果之評估 = Applications of polyzwitterions to modify nonwovens and their assessment of anti-fouling properties
徐, 千祐

利用聚雙性分子改質不織布及其抗沾黏效果之評估 = Applications of polyzwitterions to modify nonwovens and their assessment of anti-fouling properties / 徐千祐撰 - [高雄市] : 撰者, 2012[民101]. - 87面 ; 圖，表格 ; 30公分.
106年10月31日公開參考書目：面71-74.
不織布non-woven

利用聚雙性分子改質不織布及其抗沾黏效果之評估 = Applications of polyzwitterions to modify nonwovens and their assessment of anti-fouling properties
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