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Responsive Networks for Biofunctiona...

Pao, Chih-Ning.

Responsive Networks for Biofunctional Molecules Delivery System.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Responsive Networks for Biofunctional Molecules Delivery System.
作者:	Pao, Chih-Ning.
面頁冊數:	95 p.
附註:	Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: 3773.
附註:	Adviser: Yunfeng Lu.
Contained By:	Dissertation Abstracts International73-06B.
標題:	Engineering, Biomedical.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3497450
ISBN:	9781267185662

Responsive Networks for Biofunctional Molecules Delivery System.
Pao, Chih-Ning.

Responsive Networks for Biofunctional Molecules Delivery System. - 95 p.

Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: 3773.

Thesis (Ph.D.)--University of California, Los Angeles, 2012.

Advanced drug or other therapeutic have drawn intensive research interest for the past few decades due to the huge progresses in areas of molecular biology, genomics, and proteomics, etc. Many bio-functional molecules, especially with sophisticated structures and function agents such as enzymes have been proposed for therapeutic application. However, systematically delivering these molecules into the target area remains an insurmountable obstacle for therapeutic efficiency. In accordance the issue, low side-effect and responsive (i.e. being able to selectively localize and release the drug) delivery system has also become a prospering research topic.

ISBN: 9781267185662Subjects--Topical Terms:

227004
Engineering, Biomedical.

Responsive Networks for Biofunctional Molecules Delivery System.
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500 $a Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: 3773.
500 $a Adviser: Yunfeng Lu.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2012.
520 $a Advanced drug or other therapeutic have drawn intensive research interest for the past few decades due to the huge progresses in areas of molecular biology, genomics, and proteomics, etc. Many bio-functional molecules, especially with sophisticated structures and function agents such as enzymes have been proposed for therapeutic application. However, systematically delivering these molecules into the target area remains an insurmountable obstacle for therapeutic efficiency. In accordance the issue, low side-effect and responsive (i.e. being able to selectively localize and release the drug) delivery system has also become a prospering research topic.
520 $a To adapt the complexity in human bodies, a multi-functional and even multi-targeting delivery system is required to maximize the efficiency. To collect complex functions into relative simple system (considering the feasibility of fabrication), this work propose the concept of utilizing the molecular interactions of the whole delivery system. It is to treat the interactions within the system or between the system and the environment as components of total functionality as well as the functions from original properties of the materials. By researching and understanding the environmental changes in the body, the interactions can be and manipulated through proper design of the system. The first and second parts of the thesis describe the design and examination of thermo or pH responsive delivery systems via self-assembly of PCDA/PAA or PEI/plasmid DNA particles.
520 $a This work also exploits the issue of the trade-off between responsiveness and stability. It is addressed in the first two parts, introducing the covalent network to stabilize the structure while still preserve adequate responsiveness. The tuning process of the trade-off is also reported to show the spectra from sensitive/unstable to insensitive/stable by monitoring the content release or transfection. The last portion of the thesis is the attempt to build multi targeting gene delivery system by controlling both protamine/DNA assembly and the modification of targeting ligands.
520 $a Overall this work demonstrates the concept of hierarchical functions by combining and tuning (via hybridization of covalent link) the interactions and materials together in designing simple yet powerful delivery systems.
590 $a School code: 0031.
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