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Neurobiology of Huntington's disease...

Hughes, Robert E., (Ph.D.)

Neurobiology of Huntington's diseaseapplications to drug discovery /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Neurobiology of Huntington's diseaseedited by Donald C. Lo and Robert E. Hughes.
其他題名:	applications to drug discovery /
其他作者:	Lo, Donald C.
出版者:	Boca Raton :CRC Press/Taylor & Francis Group,2010.
面頁冊數:	1 online resource :ill. (some col.).
標題:	Huntington's choreaPathophysiology.
電子資源:	http://www.crcnetbase.com/isbn/978-0-8493-9000-5
ISBN:	9781420008258 (e-book : PDF)

Neurobiology of Huntington's diseaseapplications to drug discovery /
Neurobiology of Huntington's diseaseapplications to drug discovery /[electronic resource] :edited by Donald C. Lo and Robert E. Hughes. - Boca Raton :CRC Press/Taylor & Francis Group,2010. - 1 online resource :ill. (some col.). - Frontiers in neuroscience. - Frontiers in neuroscience (Boca Raton, Fla.).

Includes bibliographical references.

"Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description.

ISBN: 9781420008258 (e-book : PDF)Subjects--Topical Terms:

648539
Huntington's chorea
--Pathophysiology.Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RC394.H85 / N48 2010

Dewey Class. No.: 616.851 / N494

National Library of Medicine Call No.: WL 390

Neurobiology of Huntington's diseaseapplications to drug discovery /
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520 $a "Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description.
588 $a Description based on print version record.
650 0 $a Huntington's chorea $x Pathophysiology. $3 648539
650 0 $a Huntington's chorea $x Molecular aspects. $3 648540
650 0 $a Neuropharmacology. $3 275141
650 1 2 $a Huntington Disease $x physiopathology. $3 648541
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