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An analytical and experimental biose...

The University of Texas - Pan American.

An analytical and experimental biosensor for human MIG using AlGaN/GaN based HEMT devices.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	An analytical and experimental biosensor for human MIG using AlGaN/GaN based HEMT devices.
作者:	Trevino, Hector, II.
面頁冊數:	172 p.
附註:	Source: Masters Abstracts International, Volume: 53-02.
附註:	Adviser: Hasina F. Huq.
Contained By:	Masters Abstracts International53-02(E).
標題:	Electrical engineering.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1560013
ISBN:	9781321010732

An analytical and experimental biosensor for human MIG using AlGaN/GaN based HEMT devices.
Trevino, Hector, II.

An analytical and experimental biosensor for human MIG using AlGaN/GaN based HEMT devices. - 172 p.

Source: Masters Abstracts International, Volume: 53-02.

Thesis (M.S.)--The University of Texas - Pan American, 2014.

This item must not be sold to any third party vendors.

An amperometric biosensor using AlGaN/GaN based HEMT devices is constructed experimentally and validated through analytical and numerical techniques for detection of a key protein in allograft rejection (Human MIG/CXCL9). The prototype developed provides a reliable sensing platform that will allow label-free and marker-free detection. By exploiting characteristics unique to AlGaN/GaN based HEMT devices, a floating gate configuration is employed to allow reliable sensing without the need for any reference electrode. This ensures that any response in drain current will be attributed to the bio-conugation of the target antibody with its appropriate analyte. Self-assembled monolayers (SAM) are formed at the gate surface by using a crosslinker (DSP) to allow for appropriate immobilization of target antibodies. A theoretical analytical and numerical model is developed using the Charge-control and net neutrality equations to explain the mechanism of action of the proposed biosensor. Furthermore, other issues such as repeatability, influence of the substrate, threshold shifting, and device packaging are addressed. Finally, an experimental circuit is constructed with the previously prepared biosensor to validate the claims made in this thesis.

ISBN: 9781321010732Subjects--Topical Terms:

454503
Electrical engineering.

An analytical and experimental biosensor for human MIG using AlGaN/GaN based HEMT devices.
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506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a An amperometric biosensor using AlGaN/GaN based HEMT devices is constructed experimentally and validated through analytical and numerical techniques for detection of a key protein in allograft rejection (Human MIG/CXCL9). The prototype developed provides a reliable sensing platform that will allow label-free and marker-free detection. By exploiting characteristics unique to AlGaN/GaN based HEMT devices, a floating gate configuration is employed to allow reliable sensing without the need for any reference electrode. This ensures that any response in drain current will be attributed to the bio-conugation of the target antibody with its appropriate analyte. Self-assembled monolayers (SAM) are formed at the gate surface by using a crosslinker (DSP) to allow for appropriate immobilization of target antibodies. A theoretical analytical and numerical model is developed using the Charge-control and net neutrality equations to explain the mechanism of action of the proposed biosensor. Furthermore, other issues such as repeatability, influence of the substrate, threshold shifting, and device packaging are addressed. Finally, an experimental circuit is constructed with the previously prepared biosensor to validate the claims made in this thesis.
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