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Characterization of new mouse circad...

Annayev, Yunus.

Characterization of new mouse circadian clock gene: Gm129.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterization of new mouse circadian clock gene: Gm129.
作者:	Annayev, Yunus.
面頁冊數:	59 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
附註:	Advisers: Aziz Sancar; Greg Wang.
Contained By:	Dissertation Abstracts International76-01B(E).
標題:	Biochemistry.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3633921
ISBN:	9781321140873

Characterization of new mouse circadian clock gene: Gm129.
Annayev, Yunus.

Characterization of new mouse circadian clock gene: Gm129. - 59 p.

Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2014.

This item must not be sold to any third party vendors.

Circadian clock is a 24hr rhythmicity that controls behavioral, metabolic events in most of the organisms. It has been reported that around 10% of all transcripts in mice show circadian expression pattern. The circadian clock is regulated by core clock which in most organisms is controlled by a transcription-translation feedback loop (TTFL). Transcriptional activators constitute positive arm of the TTFL and transcriptional repressors constitute the negative arm of the (TTFL).

ISBN: 9781321140873Subjects--Topical Terms:

188609
Biochemistry.

Characterization of new mouse circadian clock gene: Gm129.
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245 1 0 $a Characterization of new mouse circadian clock gene: Gm129.
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500 $a Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
500 $a Advisers: Aziz Sancar; Greg Wang.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Circadian clock is a 24hr rhythmicity that controls behavioral, metabolic events in most of the organisms. It has been reported that around 10% of all transcripts in mice show circadian expression pattern. The circadian clock is regulated by core clock which in most organisms is controlled by a transcription-translation feedback loop (TTFL). Transcriptional activators constitute positive arm of the TTFL and transcriptional repressors constitute the negative arm of the (TTFL).
520 $a In a ChIPseq analysis in mice liver we found that core clock genes bind strongly to the promoter of a previously uncharacterized gene called Gene Model 129 (Gm129). Gm129 transcript and the protein show a very high amplitude oscillation in mouse liver. Given these core clock gene like characteristics of Gm129, I analyzed its function in the core clock and found that it interacts with BMAL1 and PER2. Additionally, Gm129 binds to BMAL1/DNA complex both in vitro and in vivo. In the reporter gene assay it inhibits CLOCK/BMAL1 induced transcription suggesting that it functions as a repressor. Gm129 knock-out mice show altered circadian transcription of clock genes and this effect is more dramatic when Gm129 mutation was combined with Cry1 mutation.
520 $a Overall, I have demonstrated that Gm129 is novel circadian clock repressor. Characterization of Gm129 provides more insight on how the circadian clock machinery functions in mammalian organisms.
590 $a School code: 0153.
650 4 $a Biochemistry. $3 188609
650 4 $a Molecular biology. $3 188737
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710 2 $a The University of North Carolina at Chapel Hill. $b Biochemistry and Biophysics. $3 708723
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