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Genetics of the mouse

Guenet, Jean Louis.

Genetics of the mouse

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Genetics of the mouseby Jean Louis Guenet ... [et al.].
其他作者:	Guenet, Jean Louis.
出版者:	Berlin, Heidelberg :Springer Berlin Heidelberg :2015.
面頁冊數:	xvii, 408 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Genetics.
電子資源:	http://dx.doi.org/10.1007/978-3-662-44287-6
ISBN:	9783662442876 (electronic bk.)

Genetics of the mouse
Genetics of the mouse[electronic resource] /by Jean Louis Guenet ... [et al.]. - Berlin, Heidelberg :Springer Berlin Heidelberg :2015. - xvii, 408 p. :ill., digital ;24 cm.

Origins of the Laboratory Mouse -- Basic Concepts of Reproductive Biology And Genetics -- Cytogenetics -- Gene Mapping -- The Mouse Genome -- Epigenetic Control of Genome Expression -- Mutations and Experimental Mutagenesis -- Transgenesis and Transgenic Animals -- The Different Categories of Genetically Standardized Populations of Laboratory Mice -- Quantitative Traits and Quantitative Genetics.

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

ISBN: 9783662442876 (electronic bk.)

Standard No.: 10.1007/978-3-662-44287-6doiSubjects--Topical Terms:

189015
Genetics.

LC Class. No.: QH431

Dewey Class. No.: 575.12

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245 0 0 $a Genetics of the mouse $h [electronic resource] / $c by Jean Louis Guenet ... [et al.].
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520 $a This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
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