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The Hsp60 chaperonin

Bross, Peter.

The Hsp60 chaperonin

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Hsp60 chaperoninby Peter Bross.
作者:	Bross, Peter.
出版者:	Cham :Springer International Publishing :2015.
面頁冊數:	xi, 85 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Molecular chaperones.
電子資源:	http://dx.doi.org/10.1007/978-3-319-26088-4
ISBN:	9783319260884$q(electronic bk.)

The Hsp60 chaperonin
Bross, Peter.

The Hsp60 chaperonin[electronic resource] /by Peter Bross. - Cham :Springer International Publishing :2015. - xi, 85 p. :ill., digital ;24 cm. - SpringerBriefs in molecular science,2191-5407. - SpringerBriefs in molecular science..

Introduction -- Historical sketch of the discovery and recognition of the function of chaperonins -- Molecular structure of chaperonins -- Folding by enclosure in the chaperonin cavity -- Evolutionary origins and family relations -- Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers? -- Sequence variations in proteins affecting chaperonin dependence -- Genetic organization of type I chaperonin genes -- Regulation of type I chaperonin gene expression -- Subcellular localization -- Posttranslational modifications -- Variations in Hsp60 and Hsp10 in humans -- Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes -- Human diseases caused by genetic mutations in the Hsp60/Hsp10 system -- Molecular investigations of disease mechanisms -- Molecular investigations of disease mechanisms -- Outlook.

In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.

ISBN: 9783319260884$q(electronic bk.)

Standard No.: 10.1007/978-3-319-26088-4doiSubjects--Topical Terms:

188662
Molecular chaperones.

LC Class. No.: QP552.M64

Dewey Class. No.: 572.6

The Hsp60 chaperonin
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