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The comprehensive sourcebook of bact...

Alouf, J. E.

The comprehensive sourcebook of bacterial protein toxins

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The comprehensive sourcebook of bacterial protein toxins[edited by] Joseph E. Alouf, Daniel Ladant, Michel R. Popoff.
其他題名:	Bacterial protein toxins
其他作者:	Alouf, J. E.
出版者:	Amsterdam :Academic Press,c2015.
面頁冊數:	1 online resource (xviii, 1182 p.) :ill.
標題:	Bacterial toxins.
電子資源:	click for full text
ISBN:	9780128005897 (electronic bk.)

The comprehensive sourcebook of bacterial protein toxins
The comprehensive sourcebook of bacterial protein toxins[electronic resource] /Bacterial protein toxins[edited by] Joseph E. Alouf, Daniel Ladant, Michel R. Popoff. - 4th ed. - Amsterdam :Academic Press,c2015. - 1 online resource (xviii, 1182 p.) :ill.

Includes bibliographical references and index.

Ch. 1. A 116-year story of bacterial protein toxins (1888-2004): from "diphtheritic poison" to molecular toxinology -- Ch. 2. Evolutionary aspects of toxin-producing bacteria-- Ch. 3. Mobile genetic elements and pathogenicity islands encoding bacterial toxins -- Ch. 4. Regulation systems of toxin expression -- Ch. 5. Toxin secretion systems -- Ch. 6. Toxin receptors -- Ch. 7. Translocation of bacterial protein toxin into the cytosol -- Ch. 8. Intracellular trafficking of bacterial and plant protein toxins -- Ch. 9. Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular -- Ch. 10. Bacterial toxins and mitochondria -- Ch. 11. Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries -- Ch. 12. Molecular, functional, and evolutionary aspects of ADP-ribosylating toxins -- Ch. 13. Diphtheria toxin -- Ch. 14. Pseudomonas aeruginosa toxins -- Ch. 15. Vibrio cholerae and Escherichia coli thermolabile enterotoxin -- Ch. 16. Bordetella protein toxins -- Ch. 17. The Shiga toxins: properties and action on cells -- Ch. 18. Bacillus anthracis toxins -- Ch. 19. Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular actions -- Ch. 20. Uptake and transport of clostridium neurotoxins -- Ch. 21. Large clostridial cytotoxins modifying small GTPases -- Ch. 22. Pasteurella multocida toxin -- Ch. 23. Cytolethal distending toxins --Ch. 24. Helicobacter pylori vacuolating toxin -- Ch. 25. Escherichia coli heat-stable enterotoxin b -- Ch. 26. Paradigms and classification of bacterial membrane-damaging toxins -- Ch. 27. . Membrane-damaging and cytotoxic phospholipases -- Ch. 28. Bacteroidesfragilis toxins -- Ch. 29. Structure and mode of action of RTX toxins

Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial proteintoxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.

ISBN: 9780128005897 (electronic bk.)Subjects--Topical Terms:

195253
Bacterial toxins.

LC Class. No.: QH588.S83

Dewey Class. No.: 615.95293

National Library of Medicine Call No.: QW630.5.B2 / C738s 2015

The comprehensive sourcebook of bacterial protein toxins
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505 0 $a Ch. 1. A 116-year story of bacterial protein toxins (1888-2004): from "diphtheritic poison" to molecular toxinology -- Ch. 2. Evolutionary aspects of toxin-producing bacteria-- Ch. 3. Mobile genetic elements and pathogenicity islands encoding bacterial toxins -- Ch. 4. Regulation systems of toxin expression -- Ch. 5. Toxin secretion systems -- Ch. 6. Toxin receptors -- Ch. 7. Translocation of bacterial protein toxin into the cytosol -- Ch. 8. Intracellular trafficking of bacterial and plant protein toxins -- Ch. 9. Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular -- Ch. 10. Bacterial toxins and mitochondria -- Ch. 11. Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries -- Ch. 12. Molecular, functional, and evolutionary aspects of ADP-ribosylating toxins -- Ch. 13. Diphtheria toxin -- Ch. 14. Pseudomonas aeruginosa toxins -- Ch. 15. Vibrio cholerae and Escherichia coli thermolabile enterotoxin -- Ch. 16. Bordetella protein toxins -- Ch. 17. The Shiga toxins: properties and action on cells -- Ch. 18. Bacillus anthracis toxins -- Ch. 19. Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular actions -- Ch. 20. Uptake and transport of clostridium neurotoxins -- Ch. 21. Large clostridial cytotoxins modifying small GTPases -- Ch. 22. Pasteurella multocida toxin -- Ch. 23. Cytolethal distending toxins --Ch. 24. Helicobacter pylori vacuolating toxin -- Ch. 25. Escherichia coli heat-stable enterotoxin b -- Ch. 26. Paradigms and classification of bacterial membrane-damaging toxins -- Ch. 27. . Membrane-damaging and cytotoxic phospholipases -- Ch. 28. Bacteroidesfragilis toxins -- Ch. 29. Structure and mode of action of RTX toxins
520 $a Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial proteintoxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.
650 0 $a Bacterial toxins. $3 195253
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