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Pharmacokinetic and pharmacodynamic ...

Ensom, Mary H.H.

Pharmacokinetic and pharmacodynamic drug interactions associated with antiretroviral drugs

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Pharmacokinetic and pharmacodynamic drug interactions associated with antiretroviral drugsedited by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom.
其他作者:	Kiang, Tony K.L.
出版者:	Singapore :Springer Singapore :2016.
面頁冊數:	vii, 135 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Antiretroviral agents.
電子資源:	http://dx.doi.org/10.1007/978-981-10-2113-8
ISBN:	9789811021138$q(electronic bk.)

Pharmacokinetic and pharmacodynamic drug interactions associated with antiretroviral drugs
Pharmacokinetic and pharmacodynamic drug interactions associated with antiretroviral drugs[electronic resource] /edited by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom. - Singapore :Springer Singapore :2016. - vii, 135 p. :ill., digital ;24 cm.

1. Introduction -- 2. HIV-Associated Comorbidities -- 3. Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals -- 4. In Vitro Reaction Phenotyping and Drug Interaction Data -- 5. Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents -- 6. Clinical Drug-Drug Interaction Data: Effects of Antiretroviral Agents on Co-administered Drugs -- 7. Pharmacodynamic Interactions Between Antiretrovirals and Other Agents -- 8. Conclusion and Clinical Decision Algorithm.

Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today.

ISBN: 9789811021138$q(electronic bk.)

Standard No.: 10.1007/978-981-10-2113-8doiSubjects--Topical Terms:

281148
Antiretroviral agents.

LC Class. No.: RC606.7

Dewey Class. No.: 615.7924

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505 0 $a 1. Introduction -- 2. HIV-Associated Comorbidities -- 3. Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals -- 4. In Vitro Reaction Phenotyping and Drug Interaction Data -- 5. Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents -- 6. Clinical Drug-Drug Interaction Data: Effects of Antiretroviral Agents on Co-administered Drugs -- 7. Pharmacodynamic Interactions Between Antiretrovirals and Other Agents -- 8. Conclusion and Clinical Decision Algorithm.
520 $a Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today.
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