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Safety and efficacy of gene-based th...

Brunetti-Pierri, Nicola.

Safety and efficacy of gene-based therapeutics for inherited disorders

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Safety and efficacy of gene-based therapeutics for inherited disordersedited by Nicola Brunetti-Pierri.
其他作者:	Brunetti-Pierri, Nicola.
出版者:	Cham :Springer International Publishing :2017.
面頁冊數:	ix, 220 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Genetic disordersGene therapy.
電子資源:	http://dx.doi.org/10.1007/978-3-319-53457-2
ISBN:	9783319534572$q(electronic bk.)

Safety and efficacy of gene-based therapeutics for inherited disorders
Safety and efficacy of gene-based therapeutics for inherited disorders[electronic resource] /edited by Nicola Brunetti-Pierri. - Cham :Springer International Publishing :2017. - ix, 220 p. :ill., digital ;24 cm.

Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.

ISBN: 9783319534572$q(electronic bk.)

Standard No.: 10.1007/978-3-319-53457-2doiSubjects--Topical Terms:

785028
Genetic disorders
--Gene therapy.

LC Class. No.: RB155.8

Dewey Class. No.: 616.042

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