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MIF family cytokines in innate immun...

Bernhagen, Jurgen.

MIF family cytokines in innate immunity and homeostasis

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	MIF family cytokines in innate immunity and homeostasisedited by Richard Bucala, Jurgen Bernhagen.
其他作者:	Bucala, Richard.
出版者:	Cham :Springer International Publishing :2017.
面頁冊數:	viii, 246 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
標題:	Cytokines.
電子資源:	http://dx.doi.org/10.1007/978-3-319-52354-5
ISBN:	9783319523545$q(electronic bk.)

MIF family cytokines in innate immunity and homeostasis
MIF family cytokines in innate immunity and homeostasis[electronic resource] /edited by Richard Bucala, Jurgen Bernhagen. - Cham :Springer International Publishing :2017. - viii, 246 p. :ill. (some col.), digital ;24 cm. - Progress in inflammation research. - Progress in inflammation research..

MIF and CD74-dependent Mechanisms -- HSP90-stabilized MIF in Oncogenesis and Cell Growth Control- CD74, MIF, and Breast Tumorigenesis: Insights from Recent Large-scale Tumor Genomics and Proteomics Studies -- MIF-dependent Regulation of Monocyte/Macrophage Polarization -- Advances in understanding the role of MIF in the pathogenesis of autoimmune diseases -- Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis -- Role of MIF in Hepatic Inflammatory Diseases and Fibrosis -- MIF and Pulmonary Disease -- MIF Mediates Pelvic Inflammation and Pain -- MIF Family Proteins in Cardiac Ischemia / Reperfusion Injury -- The MIF-CD74 Inflammatory Axis in Alphaviral Infection -- MIF in Eosinophilic Inflammation -- The Role of MIF in Parasitic Infections -- Parasite MIF Orthologs.

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

ISBN: 9783319523545$q(electronic bk.)

Standard No.: 10.1007/978-3-319-52354-5doiSubjects--Topical Terms:

195178
Cytokines.

LC Class. No.: QR185.8.C95

Dewey Class. No.: 616.079

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520 $a The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
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