語系:
繁體中文
English
說明(常見問題)
圖資館首頁
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Planning and analyzing clinical tria...
~
Kieser, Meinhard.
Planning and analyzing clinical trials with composite endpoints
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Planning and analyzing clinical trials with composite endpointsby Geraldine Rauch, Svenja Schuler, Meinhard Kieser.
作者:
Rauch, Geraldine.
其他作者:
Schuler, Svenja.
出版者:
Cham :Springer International Publishing :2017.
面頁冊數:
xvi, 255 p. :ill., digital ;24 cm.
Contained By:
Springer eBooks
標題:
Clinical trialsStatistical methods.
電子資源:
http://dx.doi.org/10.1007/978-3-319-73770-6
ISBN:
9783319737706$q(electronic bk.)
Planning and analyzing clinical trials with composite endpoints
Rauch, Geraldine.
Planning and analyzing clinical trials with composite endpoints
[electronic resource] /by Geraldine Rauch, Svenja Schuler, Meinhard Kieser. - Cham :Springer International Publishing :2017. - xvi, 255 p. :ill., digital ;24 cm. - Springer series in pharmaceutical statistics,2366-8695. - Springer series in pharmaceutical statistics..
Preface -- Contents -- Part I General Introduction to Composite Endpoints -- 1 Definition and Rationale -- 2 Challenges of Composite Endpoints -- 3 Guideline View - Recommendations and Requirements -- 4 Clinical Trial Examples -- Part II Confirmatory Test Problem for a Single (Composite) Endpoint -- 5 The Single-Stage Design -- 6 Group-Sequential and Adaptive Designs -- 7 Related Software Code -- Part III Confirmatory Multiple Test Problem -- 8 Correlation Between Test Statistics -- 9 The Single-Stage Design -- 10 Group-Sequential and Adaptive Designs -- 11 Related Software Code -- Part IV Confirmatory Test Problem for a Weighted Composite Endpoint -- 12 Weighted Binary Composite Endpoint -- Weighted Time-to-Event Composite Endpoint -- 14 OtherWeighted Effect Measures -- 15 Related Software Code -- Part V Descriptive and Confirmatory Evaluation of the Components -- 16 Descriptive Analysis of the Components -- 17 Supplementary Confirmatory Analyses of the Components -- 18 Related Software Code -- Part VI Illustrating Clinical Trial Examples -- 19 Clinical Trial Examples with Binary (Composite) Endpoints -- 20 Clinical Trial Examples with (Composite) Time-to-Event Endpoints.
This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful. The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from the book, readers should be familiar with the principles of clinical trials and basic statistical methods.
ISBN: 9783319737706$q(electronic bk.)
Standard No.: 10.1007/978-3-319-73770-6doiSubjects--Topical Terms:
181899
Clinical trials
--Statistical methods.
LC Class. No.: R853.C55
Dewey Class. No.: 610.727
Planning and analyzing clinical trials with composite endpoints
LDR
:03484nmm a2200301 a 4500
001
526109
003
DE-He213
005
20180523022233.0
006
m d
007
cr nn 008maaau
008
180928s2017 gw s 0 eng d
020
$a
9783319737706$q(electronic bk.)
020
$a
9783319737690$q(paper)
024
7
$a
10.1007/978-3-319-73770-6
$2
doi
035
$a
978-3-319-73770-6
040
$a
GP
$c
GP
041
0
$a
eng
050
4
$a
R853.C55
082
0 4
$a
610.727
$2
23
090
$a
R853.C55
$b
R241 2017
100
1
$a
Rauch, Geraldine.
$3
798768
245
1 0
$a
Planning and analyzing clinical trials with composite endpoints
$h
[electronic resource] /
$c
by Geraldine Rauch, Svenja Schuler, Meinhard Kieser.
260
$a
Cham :
$b
Springer International Publishing :
$b
Imprint: Springer,
$c
2017.
300
$a
xvi, 255 p. :
$b
ill., digital ;
$c
24 cm.
490
1
$a
Springer series in pharmaceutical statistics,
$x
2366-8695
505
0
$a
Preface -- Contents -- Part I General Introduction to Composite Endpoints -- 1 Definition and Rationale -- 2 Challenges of Composite Endpoints -- 3 Guideline View - Recommendations and Requirements -- 4 Clinical Trial Examples -- Part II Confirmatory Test Problem for a Single (Composite) Endpoint -- 5 The Single-Stage Design -- 6 Group-Sequential and Adaptive Designs -- 7 Related Software Code -- Part III Confirmatory Multiple Test Problem -- 8 Correlation Between Test Statistics -- 9 The Single-Stage Design -- 10 Group-Sequential and Adaptive Designs -- 11 Related Software Code -- Part IV Confirmatory Test Problem for a Weighted Composite Endpoint -- 12 Weighted Binary Composite Endpoint -- Weighted Time-to-Event Composite Endpoint -- 14 OtherWeighted Effect Measures -- 15 Related Software Code -- Part V Descriptive and Confirmatory Evaluation of the Components -- 16 Descriptive Analysis of the Components -- 17 Supplementary Confirmatory Analyses of the Components -- 18 Related Software Code -- Part VI Illustrating Clinical Trial Examples -- 19 Clinical Trial Examples with Binary (Composite) Endpoints -- 20 Clinical Trial Examples with (Composite) Time-to-Event Endpoints.
520
$a
This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful. The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from the book, readers should be familiar with the principles of clinical trials and basic statistical methods.
650
0
$a
Clinical trials
$x
Statistical methods.
$3
181899
650
1 4
$a
Statistics.
$3
182057
650
2 4
$a
Statistics for Life Sciences, Medicine, Health Sciences.
$3
274067
650
2 4
$a
Biostatistics.
$3
339693
650
2 4
$a
Pharmaceutical Sciences/Technology.
$3
338426
700
1
$a
Schuler, Svenja.
$3
798769
700
1
$a
Kieser, Meinhard.
$3
798770
710
2
$a
SpringerLink (Online service)
$3
273601
773
0
$t
Springer eBooks
830
0
$a
Springer series in pharmaceutical statistics.
$3
753654
856
4 0
$u
http://dx.doi.org/10.1007/978-3-319-73770-6
950
$a
Mathematics and Statistics (Springer-11649)
筆 0 讀者評論
全部
電子館藏
館藏
1 筆 • 頁數 1 •
1
條碼號
館藏地
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
000000149213
電子館藏
1圖書
電子書
EB R853.C55 R241 2017 2017
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
多媒體檔案
http://dx.doi.org/10.1007/978-3-319-73770-6
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼
登入