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Molecular recognition of DNA double ...

Saha, Abhijit.

Molecular recognition of DNA double helixgene regulation and photochemistry of BrU substituted DNA /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Molecular recognition of DNA double helixby Abhijit Saha.
其他題名:	gene regulation and photochemistry of BrU substituted DNA /
作者:	Saha, Abhijit.
出版者:	Singapore :Springer Singapore :2018.
面頁冊數:	xvi, 114 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
標題:	DNA.
電子資源:	http://dx.doi.org/10.1007/978-981-10-8746-2
ISBN:	9789811087462$q(electronic bk.)

Molecular recognition of DNA double helixgene regulation and photochemistry of BrU substituted DNA /
Saha, Abhijit.

Molecular recognition of DNA double helixgene regulation and photochemistry of BrU substituted DNA /[electronic resource] :by Abhijit Saha. - Singapore :Springer Singapore :2018. - xvi, 114 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

1. Overview of DNA minor groove binding synthetic small molecules and photochemistry of BrU substituted DNA -- 2. Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity -- 3. Chemical Modification of a Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast -- 4. Development of a novel photochemical detection technique for the analysis of polyamide binding sites -- 5. Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay -- 6.UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258.

In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book.

ISBN: 9789811087462$q(electronic bk.)

Standard No.: 10.1007/978-981-10-8746-2doiSubjects--Topical Terms:

176585
DNA.

LC Class. No.: QP624 / .S243 2018

Dewey Class. No.: 572.86

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520 $a In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book.
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