國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Total synthesis of natural products ...

Giltrap, Andrew.

Total synthesis of natural products with antimicrobial activity

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Total synthesis of natural products with antimicrobial activityby Andrew Giltrap.
作者:	Giltrap, Andrew.
出版者:	Singapore :Springer Singapore :2018.
面頁冊數:	xxiv, 268 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
標題:	Natural products.
電子資源:	http://dx.doi.org/10.1007/978-981-10-8806-3
ISBN:	9789811088063$q(electronic bk.)

Total synthesis of natural products with antimicrobial activity
Giltrap, Andrew.

Total synthesis of natural products with antimicrobial activity[electronic resource] /by Andrew Giltrap. - Singapore :Springer Singapore :2018. - xxiv, 268 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

ISBN: 9789811088063$q(electronic bk.)

Standard No.: 10.1007/978-981-10-8806-3doiSubjects--Topical Terms:

193848
Natural products.

LC Class. No.: QD375 / .G558 2018

Dewey Class. No.: 615.792

Total synthesis of natural products with antimicrobial activity
LDR:02033nmm a2200325 a 4500 001 537656
003 DE-He213
005 20181106152426.0
006 m d
007 cr nn 008maaau
008 190116s2018 si s 0 eng d
020 $a 9789811088063$q(electronic bk.)
020 $a 9789811088056$q(paper)
024 7 $a 10.1007/978-981-10-8806-3 $2 doi
035 $a 978-981-10-8806-3
040 $a GP $c GP
041 0 $a eng
050 4 $a QD375 $b .G558 2018
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
082 0 4 $a 615.792 $2 23
090 $a QD375 $b .G489 2018
100 1 $a Giltrap, Andrew. $3 814699
245 1 0 $a Total synthesis of natural products with antimicrobial activity $h [electronic resource] / $c by Andrew Giltrap.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2018.
300 $a xxiv, 268 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.
520 $a This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
650 0 $a Natural products. $3 193848
650 0 $a Anti-infective agents. $3 204538
650 0 $a Pharmaceutical chemistry. $3 203135
650 0 $a Clinical biochemistry. $3 221284
650 1 4 $a Chemistry. $3 188628
650 2 4 $a Medicinal Chemistry. $3 275183
650 2 4 $a Medical Biochemistry. $3 274286
650 2 4 $a Drug Resistance. $3 338425
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 557607
856 4 0 $u http://dx.doi.org/10.1007/978-981-10-8806-3
950 $a Chemistry and Materials Science (Springer-11644)