國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The sliding-filament theory of muscl...

Aitchison Smith, David.

The sliding-filament theory of muscle contraction

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The sliding-filament theory of muscle contractionby David Aitchison Smith.
作者:	Aitchison Smith, David.
出版者:	Cham :Springer International Publishing :2018.
面頁冊數:	xv, 426 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Muscle contraction.
電子資源:	https://doi.org/10.1007/978-3-030-03526-6
ISBN:	9783030035266$q(electronic bk.)

The sliding-filament theory of muscle contraction
Aitchison Smith, David.

The sliding-filament theory of muscle contraction[electronic resource] /by David Aitchison Smith. - Cham :Springer International Publishing :2018. - xv, 426 p. :ill., digital ;24 cm.

Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.

ISBN: 9783030035266$q(electronic bk.)

Standard No.: 10.1007/978-3-030-03526-6doiSubjects--Topical Terms:

491928
Muscle contraction.

LC Class. No.: QP321 / .A383 2019

Dewey Class. No.: 573.75

The sliding-filament theory of muscle contraction
LDR:03292nmm a2200313 a 4500 001 548254
003 DE-He213
005 20190515095555.0
006 m d
007 cr nn 008maaau
008 190729s2018 gw s 0 eng d
020 $a 9783030035266$q(electronic bk.)
020 $a 9783030035259$q(paper)
024 7 $a 10.1007/978-3-030-03526-6 $2 doi
035 $a 978-3-030-03526-6
040 $a GP $c GP
041 0 $a eng
050 4 $a QP321 $b .A383 2019
072 7 $a MFG $2 bicssc
072 7 $a MED075000 $2 bisacsh
072 7 $a MFG $2 thema
082 0 4 $a 573.75 $2 23
090 $a QP321 $b .A311 2019
100 1 $a Aitchison Smith, David. $3 827524
245 1 4 $a The sliding-filament theory of muscle contraction $h [electronic resource] / $c by David Aitchison Smith.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2018.
300 $a xv, 426 p. : $b ill., digital ; $c 24 cm.
520 $a Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.
650 0 $a Muscle contraction. $3 491928
650 1 4 $a Human Physiology. $3 274509
650 2 4 $a Molecular Medicine. $3 273932
650 2 4 $a Cell Physiology. $3 238835
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u https://doi.org/10.1007/978-3-030-03526-6
950 $a Biomedical and Life Sciences (Springer-11642)