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Chiral photochemical scissors target...

Buranaprapuk, Apinya.

Chiral photochemical scissors targeting proteins

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Chiral photochemical scissors targeting proteinsChalla Vijaya Kumar, Apinya Buranaprapuk.
其他題名:	Foundation of artificial intelligence
作者:	Kumar, Challa V.
其他作者:	Buranaprapuk, Apinya.
出版者:	Singapore :World Scientific,c2019.
面頁冊數:	1 online resource (447 p.) :ill. (some col.)
標題:	Photochemistry.
電子資源:	https://www.worldscientific.com/worldscibooks/10.1142/10922#t=toc
ISBN:	9789813237629$q(electronic bk.)

Chiral photochemical scissors targeting proteins
Kumar, Challa V.

Chiral photochemical scissors targeting proteins[electronic resource] /Foundation of artificial intelligenceChalla Vijaya Kumar, Apinya Buranaprapuk. - 1st ed. - Singapore :World Scientific,c2019. - 1 online resource (447 p.) :ill. (some col.)

Includes bibliographical references and index.

"The remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage reaction include the exact location of the probe binding site on the protein, conformations of the bound probe at the binding site, protein size, functional groups present on the probe that interact with the protein surroundings either in a favorable or unfavorable manner, overall charge on the photoreagent, and photophysical as well as photochemical properties of the probe. The protein photocleavage studies, in all case, were preceded by detailed binding studies by a variety of spectroscopic methods. Methods as simple as absorption and fluorescence spectroscopies or more sophisticated circular dichroism spectroscopy were used. Conclusions that are most consistent with the binding data indicated a single binding site on most proteins, irrespective of the probe or the protein, with only one exception noted so far. Photoactivation of the bound probe resulted in protein cleavage at a single site, in many instances. The specificity for the reaction has been investigated in detail and molecular modeling studies provided a firm ground to rationalize the observed cleavage sites. The reagents provide unique tools for sequencing large proteins by converting them into smaller fragments by non-biochemical transformations. Understanding of the rules for the above methodology are also investigated which provided rational methods for the design of small molecules that could bind at particular sites on large proteins, and this is a major breakthrough for a variety of fields including drug design, protein targeting, mass spectrometry, proteomics and other cutting-edge research areas."--

Electronic reproduction.
Singapore :
World Scientific,
[2018]

Mode of access: World Wide Web.

ISBN: 9789813237629$q(electronic bk.)Subjects--Topical Terms:

193617
Photochemistry.

LC Class. No.: QD601.3 / .K86 2019

Dewey Class. No.: 541/.35

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520 $a "The remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage reaction include the exact location of the probe binding site on the protein, conformations of the bound probe at the binding site, protein size, functional groups present on the probe that interact with the protein surroundings either in a favorable or unfavorable manner, overall charge on the photoreagent, and photophysical as well as photochemical properties of the probe. The protein photocleavage studies, in all case, were preceded by detailed binding studies by a variety of spectroscopic methods. Methods as simple as absorption and fluorescence spectroscopies or more sophisticated circular dichroism spectroscopy were used. Conclusions that are most consistent with the binding data indicated a single binding site on most proteins, irrespective of the probe or the protein, with only one exception noted so far. Photoactivation of the bound probe resulted in protein cleavage at a single site, in many instances. The specificity for the reaction has been investigated in detail and molecular modeling studies provided a firm ground to rationalize the observed cleavage sites. The reagents provide unique tools for sequencing large proteins by converting them into smaller fragments by non-biochemical transformations. Understanding of the rules for the above methodology are also investigated which provided rational methods for the design of small molecules that could bind at particular sites on large proteins, and this is a major breakthrough for a variety of fields including drug design, protein targeting, mass spectrometry, proteomics and other cutting-edge research areas."-- $c Publisher's website.
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