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Medicinal chemistrydrug design and d...

Haldane, Thomas,

Medicinal chemistrydrug design and development /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Medicinal chemistryThomas Haldane.
其他題名:	drug design and development /
其他作者:	Haldane, Thomas,
出版者:	[New York] :World Technologies,2018.
面頁冊數:	1 online resource (232 p.)
標題:	Pharmaceutical chemistry.
電子資源:	click for full text
ISBN:	9781978914063

Medicinal chemistrydrug design and development /
Medicinal chemistrydrug design and development /[electronic resource] :Thomas Haldane. - 1st ed. - [New York] :World Technologies,2018. - 1 online resource (232 p.)

Includes bibliographical references and index.

Medicinal chemistry: drug design and development -- Contents -- Preface -- Chapter 1. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A -- Chapter 2. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids -- Chapter 3. The first total synthesis of the cyclodepsipeptide pipecolidepsin A -- Chapter 4. Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach -- Chapter 5. Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity -- Chapter 6. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations -- Chapter 7. Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs -- Chapter 8. Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator -- Chapter 9. Total synthesis of clostrubin -- Chapter 10. Downsizing a human inflammatory protein to a small molecule with equal potency and functionality -- Chapter 11. TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ<sup>9</sup>-tetrahydrocannabiorcol -- Chapter 12. De novo branching cascades for structural and functional diversity in small molecules -- Chapter 13. Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations -- Chapter 14. Solution-based circuits enable rapid and multiplexed pathogen detection -- Chapter 15. Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects -- Chapter 16. In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles -- Chapter 17. Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate -- Chapter 18. Foldamer-mediated manipulation of a pre-amyloid toxin -- Chapter 19. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds -- Chapter 20. In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics -- Chapter 21. Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity -- Chapter 22. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity -- List of Contributors -- Index.

Medicinal chemistry is the application of principles of chemistry, synthetic chemistry and pharmacology for the study and development of pharmaceutical drugs. This book on medicinal chemistry seeks to explain the methods for discovery of new therapeutic drugs and medication. This book outlines the processes and applications of medicinal chemistry in detail. It unfolds the innovative aspects of the field which will be crucial for the progress of this field in the future. This text is appropriate for students seeking detailed information in this area as well as for experts. As this field is emerging at a fast pace, this book will help the readers to better understand the concepts of medicinal chemistry

ISBN: 9781978914063Subjects--Topical Terms:

203135
Pharmaceutical chemistry.

LC Class. No.: RS403 .M43 2018

Dewey Class. No.: 615.19

Medicinal chemistrydrug design and development /
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505 0 $a Medicinal chemistry: drug design and development -- Contents -- Preface -- Chapter 1. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A -- Chapter 2. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids -- Chapter 3. The first total synthesis of the cyclodepsipeptide pipecolidepsin A -- Chapter 4. Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach -- Chapter 5. Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity -- Chapter 6. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations -- Chapter 7. Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs -- Chapter 8. Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator -- Chapter 9. Total synthesis of clostrubin -- Chapter 10. Downsizing a human inflammatory protein to a small molecule with equal potency and functionality -- Chapter 11. TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ<sup>9</sup>-tetrahydrocannabiorcol -- Chapter 12. De novo branching cascades for structural and functional diversity in small molecules -- Chapter 13. Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations -- Chapter 14. Solution-based circuits enable rapid and multiplexed pathogen detection -- Chapter 15. Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects -- Chapter 16. In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles -- Chapter 17. Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate -- Chapter 18. Foldamer-mediated manipulation of a pre-amyloid toxin -- Chapter 19. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds -- Chapter 20. In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics -- Chapter 21. Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity -- Chapter 22. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity -- List of Contributors -- Index.
520 3 $a Medicinal chemistry is the application of principles of chemistry, synthetic chemistry and pharmacology for the study and development of pharmaceutical drugs. This book on medicinal chemistry seeks to explain the methods for discovery of new therapeutic drugs and medication. This book outlines the processes and applications of medicinal chemistry in detail. It unfolds the innovative aspects of the field which will be crucial for the progress of this field in the future. This text is appropriate for students seeking detailed information in this area as well as for experts. As this field is emerging at a fast pace, this book will help the readers to better understand the concepts of medicinal chemistry
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650 0 $a Drugs $x Design. $3 201742
650 0 $a Drug development. $3 190608
650 0 $a Drugs $x Structure-activity relationships. $3 282689
650 0 $a Toxicity testing $x In vivo. $3 843026
650 0 $a Pharmacology. $3 218135
650 0 $a Pharmaceutical Sciences. $3 843021
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