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Hypoxia and cancer metastasis

Gilkes, Daniele M.

Hypoxia and cancer metastasis

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Hypoxia and cancer metastasisedited by Daniele M. Gilkes.
其他作者:	Gilkes, Daniele M.
出版者:	Cham :Springer International Publishing :2019.
面頁冊數:	viii, 160 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Cancer.
電子資源:	https://doi.org/10.1007/978-3-030-12734-3
ISBN:	9783030127343$q(electronic bk.)

Hypoxia and cancer metastasis
Hypoxia and cancer metastasis[electronic resource] /edited by Daniele M. Gilkes. - Cham :Springer International Publishing :2019. - viii, 160 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v.11360065-2598 ;. - Advances in experimental medicine and biology ;946..

Preface -- Hypoxia mediates tumor malignancy -- Clinical methods for quanitifying hypoxia in human tumors -- Hypoxia-induced phenotypes that mediate tumor heterogeneity -- Hypoxia and the tumors secretome -- Hypoxic signaling in angiogenesis and lymphangiogenesis -- Hypoxia induced metabolic reprogramming in cancer metastasis -- The metastatic niche and hypoxia -- Hypoxia and immune suppression -- Hypoxia-induced resistance to cancer therapy -- Therapeutic stratagies to target the hypoxic microenvironment -- Index.

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

ISBN: 9783030127343$q(electronic bk.)

Standard No.: 10.1007/978-3-030-12734-3doiSubjects--Topical Terms:

195182
Cancer.

LC Class. No.: RA645.C3 / H96 2019

Dewey Class. No.: 614.5999

Hypoxia and cancer metastasis
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520 $a The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
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