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DNA systems under internal and exter...

Engel, Megan Clare.

DNA systems under internal and external forcingan exploration using coarse-grained modelling /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	DNA systems under internal and external forcingby Megan Clare Engel.
其他題名:	an exploration using coarse-grained modelling /
作者:	Engel, Megan Clare.
出版者:	Cham :Springer International Publishing :2019.
面頁冊數:	xv, 144 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	DNAAnalysis.
電子資源:	https://doi.org/10.1007/978-3-030-25413-1
ISBN:	9783030254131$q(electronic bk.)

DNA systems under internal and external forcingan exploration using coarse-grained modelling /
Engel, Megan Clare.

DNA systems under internal and external forcingan exploration using coarse-grained modelling /[electronic resource] :by Megan Clare Engel. - Cham :Springer International Publishing :2019. - xv, 144 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Simulation Methods -- Non-equilibrium bio-molecular unfolding under tension -- Force-induced unravelling of DNA origami -- Measuring internal forces in single-stranded DNA -- Conclusions -- Appendices.

The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.

ISBN: 9783030254131$q(electronic bk.)

Standard No.: 10.1007/978-3-030-25413-1doiSubjects--Topical Terms:

194476
DNA
--Analysis.

LC Class. No.: QP624 / .E544 2019

Dewey Class. No.: 572.86

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