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Next Generation kinase inhibitorsmov...

Shapiro, Paul.

Next Generation kinase inhibitorsmoving beyond the ATP binding/catalytic sites /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Next Generation kinase inhibitorsedited by Paul Shapiro.
其他題名:	moving beyond the ATP binding/catalytic sites /
其他作者:	Shapiro, Paul.
出版者:	Cham :Springer International Publishing :2020.
面頁冊數:	xii, 217 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Protein kinasesInhibitors.
電子資源:	https://doi.org/10.1007/978-3-030-48283-1
ISBN:	9783030482831$q(electronic bk.)

Next Generation kinase inhibitorsmoving beyond the ATP binding/catalytic sites /
Next Generation kinase inhibitorsmoving beyond the ATP binding/catalytic sites /[electronic resource] :edited by Paul Shapiro. - Cham :Springer International Publishing :2020. - xii, 217 p. :ill., digital ;24 cm.

Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index.

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.

ISBN: 9783030482831$q(electronic bk.)

Standard No.: 10.1007/978-3-030-48283-1doiSubjects--Topical Terms:

873824
Protein kinases
--Inhibitors.

LC Class. No.: QP606.P76 / N498 2020

Dewey Class. No.: 572.792

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520 $a Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.
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