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Mammalian sterolsnovel biological ro...

Gebhardt, Rolf.

Mammalian sterolsnovel biological roles of cholesterol synthesis intermediates, oxysterols and bile acids /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mammalian sterolsedited by Damjana Rozman, Rolf Gebhardt.
其他題名:	novel biological roles of cholesterol synthesis intermediates, oxysterols and bile acids /
其他作者:	Rozman, Damjana.
出版者:	Cham :Springer International Publishing :2020.
面頁冊數:	v, 171 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Sterols.
電子資源:	https://doi.org/10.1007/978-3-030-39684-8
ISBN:	9783030396848$q(electronic bk.)

Mammalian sterolsnovel biological roles of cholesterol synthesis intermediates, oxysterols and bile acids /
Mammalian sterolsnovel biological roles of cholesterol synthesis intermediates, oxysterols and bile acids /[electronic resource] :edited by Damjana Rozman, Rolf Gebhardt. - Cham :Springer International Publishing :2020. - v, 171 p. :ill., digital ;24 cm.

Sterols from the post-lanosterol part of cholesterol synthesis - novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.

This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.

ISBN: 9783030396848$q(electronic bk.)

Standard No.: 10.1007/978-3-030-39684-8doiSubjects--Topical Terms:

302058
Sterols.

LC Class. No.: QP752.S75 / M366 2020

Dewey Class. No.: 572.5795

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505 0 $a Sterols from the post-lanosterol part of cholesterol synthesis - novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
520 $a This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
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