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Delivery of therapeutics for biogero...

Lai, Wing-Fu.

Delivery of therapeutics for biogerontological interventionsfrom concepts to experimental design /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Delivery of therapeutics for biogerontological interventionsWing-Fu Lai.
其他題名:	from concepts to experimental design /
作者:	Lai, Wing-Fu.
出版者:	London :Academic Press,2019.
面頁冊數:	1 online resource.
標題:	Geriatric pharmacology.
電子資源:	https://www.sciencedirect.com/science/book/9780128164853
ISBN:	9780128172766 (electronic bk.)

Delivery of therapeutics for biogerontological interventionsfrom concepts to experimental design /
Lai, Wing-Fu.

Delivery of therapeutics for biogerontological interventionsfrom concepts to experimental design /[electronic resource] :Wing-Fu Lai. - London :Academic Press,2019. - 1 online resource.

Includes bibliographical references and index.

Front Cover; Delivery of Therapeutics for Biogerontological Interventions; Copyright Page; Contents; Foreword; Preface; Abbreviations; I. From Concepts to Plans; 1 Theoretical frameworks for intervention development; Introduction; Areductionist approach to understand aging; Reliability theory of aging; Hypothetical frameworks for tackling aging; Reasons for the failure of an intervention; Summary; References; 2 Available delivery technologies for intervention execution; Introduction; Use of delivery technologies in interventions; Advances in delivery of nucleic acids

ISBN: 9780128172766 (electronic bk.)Subjects--Topical Terms:

375431
Geriatric pharmacology.
Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RC953.7

Dewey Class. No.: 615.1

National Library of Medicine Call No.: 2019 H-606

Delivery of therapeutics for biogerontological interventionsfrom concepts to experimental design /
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245 1 0 $a Delivery of therapeutics for biogerontological interventions $h [electronic resource] : $b from concepts to experimental design / $c Wing-Fu Lai.
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300 $a 1 online resource.
504 $a Includes bibliographical references and index.
505 0 $a Front Cover; Delivery of Therapeutics for Biogerontological Interventions; Copyright Page; Contents; Foreword; Preface; Abbreviations; I. From Concepts to Plans; 1 Theoretical frameworks for intervention development; Introduction; Areductionist approach to understand aging; Reliability theory of aging; Hypothetical frameworks for tackling aging; Reasons for the failure of an intervention; Summary; References; 2 Available delivery technologies for intervention execution; Introduction; Use of delivery technologies in interventions; Advances in delivery of nucleic acids
505 8 $a Nucleic acid delivery mediated by biological meansNucleic acid delivery mediated by chemical and physical means; Advances in delivery of nongenetic materials; Integration of engineering techniques into therapeutics delivery; Summary; References; II. From Plans to Technologies; 3 Design of viral vectors for genetic manipulation; Introduction; Engineering the properties of a viral vector; Chemical manipulation for controlled delivery; Applications in genetic manipulation; Opportunities and challenges; Summary; References; 4 Design of polymeric vectors for genetic manipulation; Introduction
505 8 $a Selection of polymeric vectorsStructural modification of polymeric vectors; Copolymerization; Functional group modification; Ligand conjugation; Optimization for intervention execution; Summary; References; 5 Design of cyclodextrin-based systems for intervention execution; Introduction; Basic properties of cyclodextrins; Strategies for structural engineering of cyclodextrins; Roles in vector design; Cyclodextrin incorporation for multifunctionality; Manipulation of host-guest complexation; Summary; References; 6 Design of upconversion nanoparticles for intervention execution; Introduction
505 8 $a Major designing principlesFabrication and morphological manipulation of upconversion nanoparticles; Generation of upconversion nanoparticle-based nucleic acid carriers; Roles of upconversion nanoparticles in nucleic acid delivery; Light-mediated control of intervention execution; Imaging and tracking of the delivery process; Optimization of upconversion nanoparticle-based nucleic acid carriers; Improvement in upconversion nanoparticle fabrication; Summary; References;7 Design of hydrogel-based nanoparticles for intervention execution; Introduction; Development of hydrogels for drug delivery
505 8 $a Design of hydrogels for intervention developmentGeneration of hydrogel nanoparticles; Ring-opening polymerization; Aqueous dispersion polymerization; Emulsion polymerization; Methods for drug loading; Strategies for cargo loading; Factors influencing the loading efficiency; Modulation of drug release; Summary; References; III. From Technologies to Interventions; 8 Use of delivery technologies to mediate RNA degradation; Introduction; Manipulation of the aging network by RNAi; Enhancement of the siRNA performance; Delivery of siRNA therapeutics; Clinical use of siRNA therapeutics
650 0 $a Geriatric pharmacology. $3 375431
650 0 $a Drug delivery systems. $3 196465
650 1 2 $a Drug Delivery Systems. $3 196468
650 2 2 $a Aging $x physiology. $3 229477
650 2 2 $a Life Expectancy. $3 897183
650 2 2 $a Geriatrics $x methods. $3 612124
655 4 $a Electronic books. $2 local. $3 214472
856 4 0 $u https://www.sciencedirect.com/science/book/9780128164853