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The secret lives of transcription factorsin heterochromatin regulation /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The secret lives of transcription factorsby Willis X. Li, Louise Silver-Morse.
其他題名:	in heterochromatin regulation /
作者:	Li, Willis X.
其他作者:	Silver-Morse, Louise.
出版者:	Cham :Springer International Publishing :2023.
面頁冊數:	vi, 45 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Transcription factors.
電子資源:	https://doi.org/10.1007/978-3-031-29029-9
ISBN:	9783031290299$q(electronic bk.)

The secret lives of transcription factorsin heterochromatin regulation /
Li, Willis X.

The secret lives of transcription factorsin heterochromatin regulation /[electronic resource] :by Willis X. Li, Louise Silver-Morse. - Cham :Springer International Publishing :2023. - vi, 45 p. :ill., digital ;24 cm. - SpringerBriefs in biochemistry and molecular biology,2211-9361. - SpringerBriefs in biochemistry and molecular biology..

Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors' unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.

This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.

ISBN: 9783031290299$q(electronic bk.)

Standard No.: 10.1007/978-3-031-29029-9doiSubjects--Topical Terms:

202406
Transcription factors.

LC Class. No.: QP552.T68 / L52 2023

Dewey Class. No.: 572.8845

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520 $a This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
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