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Hematopoietic stem cellskeystone of tissue development and regenerative medicine /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Hematopoietic stem cellsedited by Meng Zhao, Pengxu Qian.
其他題名:	keystone of tissue development and regenerative medicine /
其他作者:	Zhao, Meng.
出版者:	Singapore :Springer Nature Singapore :2023.
面頁冊數:	xv, 210 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Stem Cell Biology.
電子資源:	https://doi.org/10.1007/978-981-99-7471-9
ISBN:	9789819974719$q(electronic bk.)

Hematopoietic stem cellskeystone of tissue development and regenerative medicine /
Hematopoietic stem cellskeystone of tissue development and regenerative medicine /[electronic resource] :edited by Meng Zhao, Pengxu Qian. - Singapore :Springer Nature Singapore :2023. - xv, 210 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v. 14422214-8019 ;. - Advances in experimental medicine and biology ;946..

Chapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells.

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.

ISBN: 9789819974719$q(electronic bk.)

Standard No.: 10.1007/978-981-99-7471-9doiSubjects--Topical Terms:

921011
Stem Cell Biology.

LC Class. No.: QH588.S83

Dewey Class. No.: 616.02774

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520 $a This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.
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