國立高雄大學圖資館 |

Language: English

Back

Plant-based therapeutics.Volume 2,The brassicaceae family

Record Type:	Electronic resources : Monograph/item
Title/Author:	Plant-based therapeutics.by Ivan A. Ross.
remainder title:	Brassicaceae family
Author:	Ross, Ivan A.
Published:	Cham :Springer Nature Switzerland :2024.
Description:	xxiii, 820 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	CruciferaeTherapeutic use.
Online resource:	https://doi.org/10.1007/978-3-031-63681-3
ISBN:	9783031636813$q(electronic bk.)

Plant-based therapeutics.Volume 2,The brassicaceae family
Ross, Ivan A.

Plant-based therapeutics.Volume 2,The brassicaceae family[electronic resource] /Brassicaceae familyby Ivan A. Ross. - Cham :Springer Nature Switzerland :2024. - xxiii, 820 p. :ill., digital ;24 cm.

Ch01: The History of Brassicaceae Plants -- Ch-02: The Bioactive Components of Brassicaceae -- Ch-03: Chemical Constituents of Brassicaceae -- Ch-04: Nutrigenomics and Metabolomics of the Bioactive Compounds -- ch-05: The Anticarcinogenic Properties of Brassica Vegetables -- ch-06: Neurodegenerative Diseases -- ch-07: Epigenetic Modulation by Isothiocyanates -- ch-08: Breast Cancer -- ch-09: Brain Cancer -- ch-10: Cancer of the Gastrointestinal Tract -- ch-11: Cancer of the Urinary Bladder -- ch-12: Prostate Cancer -- Ch13: Brassica Vegetables and Hypothyroidism -- ch14: Brassicaceae and Viral Diseases -- ch15:Melatonin in Plants and Animals.

For centuries, research has been conducted on the therapeutics of Brassicaceae plants and their health-promoting effects. Cato the Elder (234-149 BCE) documented their properties in his work De agri cultura and recommended using cabbage to compress wounds, swelling, burns, and bone dislocations. For arthritis, he recommended chopped raw cabbage mixed with coriander and cured cabbage mixed with vinegar and honey. In a groundbreaking discovery in the 1990s, scientists at Johns Hopkins University isolated sulforaphane from broccoli, revealing its potent anticancer properties. This naturally occurring compound has proven highly effective, safe, and tolerable and holds immense promise as a chemoprevention agent. It has the potential to combat various cancers, including breast, prostate, gastrointestinal, melanoma, lung, brain, and bladder. But its potential does not stop there. It also shows promise in treating cardiovascular and neurodegenerative diseases and diabetes, offering hope for those affected. The cancer-protecting properties of Brassica plants are mediated through compounds that induce a variety of physiological processes, including antioxidant action, detoxifying enzymes, inducing apoptosis, and cell cycle regulation. Glucosinolate breakdown products can affect several stages of cancer development, including the inhibition of activation enzymes (phase I) and the induction of detoxification enzymes (phase II) Isothiocyanates and indole products formed from glucosinolates regulate cancer cell development by regulating target enzymes, controlling apoptosis, inhibiting angiogenesis, metastasis, and the migration of cancer cells, and blocking the cell cycle. Sulforaphane, found in abundance in broccoli sprouts, plays a crucial role in upregulating the transcriptional activity of specific genes and restoring epigenetic alterations. This is particularly significant as it modifies epigenetic pathways by targeting histone deacetylases and DNA methyltransferases. These modifications, in turn, alter gene transcription and expression, particularly in the case of cancers. This intricate process of gene regulation is a fascinating study area, making broccoli sprouts a compelling component of the 'epigenetic diet.' Sulforaphane induces the cytoprotective enzyme NQO1. The inducible expression of NQO1 is regulated principally through the Keap1-Nrf2-ARE signaling pathway. The activation of the Nrf2-Keap1 signaling pathway heralds the beneficial actions of drugs known to affect Nrf2 signaling, such as dimethyl fumarate, an FDA-approved treatment for multiple sclerosis, and bardoxolone methyl for chronic kidney disease. There is optimism that the overall strategies are moving forward. Sulforaphane-rich broccoli sprout extracts provide one avenue toward this end.

ISBN: 9783031636813$q(electronic bk.)

Standard No.: 10.1007/978-3-031-63681-3doiSubjects--Topical Terms:

983992
Cruciferae
--Therapeutic use.

LC Class. No.: QK495.C9

Dewey Class. No.: 583.78

Plant-based therapeutics.Volume 2,The brassicaceae family
LDR:04468nmm a2200337 a 4500 001 671108
003 DE-He213
005 20241019125728.0
006 m d
007 cr nn 008maaau
008 250325s2024 sz s 0 eng d
020 $a 9783031636813$q(electronic bk.)
020 $a 9783031636806$q(paper)
024 7 $a 10.1007/978-3-031-63681-3 $2 doi
035 $a 978-3-031-63681-3
040 $a GP $c GP
041 0 $a eng
050 4 $a QK495.C9
072 7 $a PST $2 bicssc
072 7 $a SCI011000 $2 bisacsh
072 7 $a PST $2 thema
082 0 4 $a 583.78 $2 23
090 $a QK495.C9 $b R824 2024
100 1 $a Ross, Ivan A. $3 273800
245 1 0 $a Plant-based therapeutics. $n Volume 2, $p The brassicaceae family $h [electronic resource] / $c by Ivan A. Ross.
246 3 0 $a Brassicaceae family
260 $a Cham : $b Springer Nature Switzerland : $b Imprint: Springer, $c 2024.
300 $a xxiii, 820 p. : $b ill., digital ; $c 24 cm.
505 0 $a Ch01: The History of Brassicaceae Plants -- Ch-02: The Bioactive Components of Brassicaceae -- Ch-03: Chemical Constituents of Brassicaceae -- Ch-04: Nutrigenomics and Metabolomics of the Bioactive Compounds -- ch-05: The Anticarcinogenic Properties of Brassica Vegetables -- ch-06: Neurodegenerative Diseases -- ch-07: Epigenetic Modulation by Isothiocyanates -- ch-08: Breast Cancer -- ch-09: Brain Cancer -- ch-10: Cancer of the Gastrointestinal Tract -- ch-11: Cancer of the Urinary Bladder -- ch-12: Prostate Cancer -- Ch13: Brassica Vegetables and Hypothyroidism -- ch14: Brassicaceae and Viral Diseases -- ch15:Melatonin in Plants and Animals.
520 $a For centuries, research has been conducted on the therapeutics of Brassicaceae plants and their health-promoting effects. Cato the Elder (234-149 BCE) documented their properties in his work De agri cultura and recommended using cabbage to compress wounds, swelling, burns, and bone dislocations. For arthritis, he recommended chopped raw cabbage mixed with coriander and cured cabbage mixed with vinegar and honey. In a groundbreaking discovery in the 1990s, scientists at Johns Hopkins University isolated sulforaphane from broccoli, revealing its potent anticancer properties. This naturally occurring compound has proven highly effective, safe, and tolerable and holds immense promise as a chemoprevention agent. It has the potential to combat various cancers, including breast, prostate, gastrointestinal, melanoma, lung, brain, and bladder. But its potential does not stop there. It also shows promise in treating cardiovascular and neurodegenerative diseases and diabetes, offering hope for those affected. The cancer-protecting properties of Brassica plants are mediated through compounds that induce a variety of physiological processes, including antioxidant action, detoxifying enzymes, inducing apoptosis, and cell cycle regulation. Glucosinolate breakdown products can affect several stages of cancer development, including the inhibition of activation enzymes (phase I) and the induction of detoxification enzymes (phase II) Isothiocyanates and indole products formed from glucosinolates regulate cancer cell development by regulating target enzymes, controlling apoptosis, inhibiting angiogenesis, metastasis, and the migration of cancer cells, and blocking the cell cycle. Sulforaphane, found in abundance in broccoli sprouts, plays a crucial role in upregulating the transcriptional activity of specific genes and restoring epigenetic alterations. This is particularly significant as it modifies epigenetic pathways by targeting histone deacetylases and DNA methyltransferases. These modifications, in turn, alter gene transcription and expression, particularly in the case of cancers. This intricate process of gene regulation is a fascinating study area, making broccoli sprouts a compelling component of the 'epigenetic diet.' Sulforaphane induces the cytoprotective enzyme NQO1. The inducible expression of NQO1 is regulated principally through the Keap1-Nrf2-ARE signaling pathway. The activation of the Nrf2-Keap1 signaling pathway heralds the beneficial actions of drugs known to affect Nrf2 signaling, such as dimethyl fumarate, an FDA-approved treatment for multiple sclerosis, and bardoxolone methyl for chronic kidney disease. There is optimism that the overall strategies are moving forward. Sulforaphane-rich broccoli sprout extracts provide one avenue toward this end.
650 0 $a Cruciferae $x Therapeutic use. $3 983992
650 1 4 $a Plant Science. $3 911813
650 2 4 $a Complementary and Alternative Medicine. $3 913063
650 2 4 $a Pharmacology. $3 218135
650 2 4 $a Medicinal Chemistry. $3 275183
650 2 4 $a Agriculture. $3 274257
650 2 4 $a Physiology. $3 192980
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-031-63681-3
950 $a Biomedical and Life Sciences (SpringerNature-11642)