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TNF pathophysiologymolecular and cel...

Kollias, G.

TNF pathophysiologymolecular and cellular mechanisms /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	TNF pathophysiologyvolume editors, G. Kollias, P.P. Sfikakis.
其他題名:	molecular and cellular mechanisms /
其他題名:	Tumor necrosis factor pathophysiology
其他作者:	Kollias, G.
出版者:	Basel :S. Karger,2010
面頁冊數:	1 online resource :ill. (some col.)
附註:	Fascinating insights into the multiple roles of this key cytokine
標題:	Tumor necrosis factorPathophysiology.
電子資源:	http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&searchWhat=books&searchParm=toc&ProduktNr=253701
ISBN:	9783805593847

TNF pathophysiologymolecular and cellular mechanisms /
TNF pathophysiologymolecular and cellular mechanisms /[electronic resource] :Tumor necrosis factor pathophysiologyvolume editors, G. Kollias, P.P. Sfikakis. - Basel :S. Karger,2010 - 1 online resource :ill. (some col.) - Current directions in autoimmunity,v.111662-2936 ;. - Current directions in autoimmunity ;v.11..

Fascinating insights into the multiple roles of this key cytokine

Includes bibliographical references and indexes.

TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems. This book is mandatory reading for molecular and cell biologists, immunologists and clinicians interested in TNF function.

ISBN: 9783805593847Subjects--Topical Terms:

520903
Tumor necrosis factor
--Pathophysiology.

LC Class. No.: QR185.8.T84 / T543 2010

Dewey Class. No.: 616.07/9

National Library of Medicine Call No.: W1 / CU788DR v.11 2010

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