國立高雄大學圖資館 |

Alzheimer's disease researchwhat has guided research so far and why it is high time for a paradigm shift /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Alzheimer's disease researchby Christian Behl.
其他題名:	what has guided research so far and why it is high time for a paradigm shift /
作者:	Behl, Christian.
出版者:	Cham :Springer International Publishing :2023.
面頁冊數:	xxv, 652 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Alzheimer's diseaseResearch.
電子資源:	https://doi.org/10.1007/978-3-031-31570-1
ISBN:	9783031315701$q(electronic bk.)

Alzheimer's disease researchwhat has guided research so far and why it is high time for a paradigm shift /
Behl, Christian.

Alzheimer's disease researchwhat has guided research so far and why it is high time for a paradigm shift /[electronic resource] :by Christian Behl. - Cham :Springer International Publishing :2023. - xxv, 652 p. :ill., digital ;24 cm.

Chapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer's Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer's Research Goes Deeper - Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer's Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer's Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer's Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer's Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer's Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer's Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change".

This book highlights the key phases and central findings of Alzheimer's Disease research since the introduction of the label 'Alzheimer's Disease' in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer's drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer's research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer's Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer's Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer's research community is finally ready to shed its 'amyloid-straitjacket' that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer's Disease research and provide a new and broader perspective on this age-dependent brain disease.

ISBN: 9783031315701$q(electronic bk.)

Standard No.: 10.1007/978-3-031-31570-1doiSubjects--Topical Terms:

275252
Alzheimer's disease
--Research.

LC Class. No.: RC523 / .B43 2023

Dewey Class. No.: 616.83110072

Alzheimer's disease researchwhat has guided research so far and why it is high time for a paradigm shift /
LDR:05484nmm a2200325 a 4500 001 648179
003 DE-He213
005 20230714014007.0
006 m d
007 cr nn 008maaau
008 240116s2023 sz s 0 eng d
020 $a 9783031315701$q(electronic bk.)
020 $a 9783031315695$q(paper)
024 7 $a 10.1007/978-3-031-31570-1 $2 doi
035 $a 978-3-031-31570-1
040 $a GP $c GP
041 0 $a eng
050 4 $a RC523 $b .B43 2023
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 616.83110072 $2 23
090 $a RC523 $b .B419 2023
100 1 $a Behl, Christian. $3 677734
245 1 0 $a Alzheimer's disease research $h [electronic resource] : $b what has guided research so far and why it is high time for a paradigm shift / $c by Christian Behl.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2023.
300 $a xxv, 652 p. : $b ill., digital ; $c 24 cm.
505 0 $a Chapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer's Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer's Research Goes Deeper - Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer's Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer's Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer's Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer's Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer's Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer's Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change".
520 $a This book highlights the key phases and central findings of Alzheimer's Disease research since the introduction of the label 'Alzheimer's Disease' in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer's drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer's research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer's Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer's Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer's research community is finally ready to shed its 'amyloid-straitjacket' that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer's Disease research and provide a new and broader perspective on this age-dependent brain disease.
650 0 $a Alzheimer's disease $x Research. $3 275252
650 1 4 $a Neuroscience. $3 297547
650 2 4 $a Neurology. $3 211583
650 2 4 $a Neurological Disorders. $3 920956
650 2 4 $a Cognitive Neuroscience. $3 846308
650 2 4 $a Neurophysiology. $3 194420
650 2 4 $a Learning and Memory. $3 922122
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-031-31570-1
950 $a Biomedical and Life Sciences (SpringerNature-11642)