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Approaching complex diseasesnetwork-...

Bizzarri, Mariano.

Approaching complex diseasesnetwork-based pharmacology and systems approach in bio-medicine /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Approaching complex diseasesedited by Mariano Bizzarri.
Reminder of title:	network-based pharmacology and systems approach in bio-medicine /
other author:	Bizzarri, Mariano.
Published:	Cham :Springer International Publishing :2020.
Description:	xvi, 483 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Drug development.
Online resource:	https://doi.org/10.1007/978-3-030-32857-3
ISBN:	9783030328573$q(electronic bk.)

Approaching complex diseasesnetwork-based pharmacology and systems approach in bio-medicine /
Approaching complex diseasesnetwork-based pharmacology and systems approach in bio-medicine /[electronic resource] :edited by Mariano Bizzarri. - Cham :Springer International Publishing :2020. - xvi, 483 p. :ill., digital ;24 cm. - Human perspectives in health sciences and technology,v.22661-8915 ;. - Human perspectives in health sciences and technology ;v.2..

This volume - for pharmacologists, systems biologists, philosophers and historians of medicine - points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

ISBN: 9783030328573$q(electronic bk.)

Standard No.: 10.1007/978-3-030-32857-3doiSubjects--Topical Terms:

190608
Drug development.

LC Class. No.: RM301.25 / .A677 2020

Dewey Class. No.: 615.10724

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