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Biomedical applications of acridines...

Hlavacek, Jan.

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Biomedical applications of acridinesby Jan Jezek, Jan Hlavacek, Jaroslav Sebestik.
其他題名:	derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /
作者:	Jezek, Jan.
其他作者:	Hlavacek, Jan.
出版者:	Cham :Springer International Publishing :2017.
面頁冊數:	xiii, 237 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Acridine.
電子資源:	http://dx.doi.org/10.1007/978-3-319-63953-6
ISBN:	9783319639536$q(electronic bk.)

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /
Jezek, Jan.

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /[electronic resource] :by Jan Jezek, Jan Hlavacek, Jaroslav Sebestik. - Cham :Springer International Publishing :2017. - xiii, 237 p. :ill., digital ;24 cm. - Progress in drug research,v.720071-786X ;. - Progress in drug research ;v.68..

Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

ISBN: 9783319639536$q(electronic bk.)

Standard No.: 10.1007/978-3-319-63953-6doiSubjects--Topical Terms:

790773
Acridine.

LC Class. No.: QP551

Dewey Class. No.: 572.6

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505 0 $a Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.
520 $a This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
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