國立高雄大學圖資館 |

登入

回首頁 到查詢結果 [ subject:"Biomedical Research." ]

Tumor suppressor Par-4structural features, molecular mechanisms and function /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Tumor suppressor Par-4edited by Vivek M. Rangnekar.
其他題名:	structural features, molecular mechanisms and function /
其他作者:	Rangnekar, Vivek.
出版者:	Cham :Springer International Publishing :2022.
面頁冊數:	x, 323 p. :ill. (chiefly col.), digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Tumor suppressor proteins.
電子資源:	https://doi.org/10.1007/978-3-030-73572-2
ISBN:	9783030735722$q(electronic bk.)

Tumor suppressor Par-4structural features, molecular mechanisms and function /
Tumor suppressor Par-4structural features, molecular mechanisms and function /[electronic resource] :edited by Vivek M. Rangnekar. - Cham :Springer International Publishing :2022. - x, 323 p. :ill. (chiefly col.), digital ;24 cm.

Discovery and Overview of Par-4 -- Par-4 in cell cycle regulation -- Conformational studies of the Par-4 C-terminal Domain -- Structural analysis of Par-4 and crystallographic analysis of the regulatory domain -- Regulation of Par-4 by Ubiquitinases -- REGULATION OF PAR-4 FUNCTION BY PHOSPHORYLATION -- Role of Par-4 in GRP78 translocation -- PAR-4 in the regulation of stem cell death and embryo development -- RASSF2 and the PAR-4 connection -- Regulation of tumor suppressor Par-4 by ceramide -- PAWR as a direct SRC-1/HOXC11 suppression target -- Index.

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

ISBN: 9783030735722$q(electronic bk.)

Standard No.: 10.1007/978-3-030-73572-2doiSubjects--Topical Terms:

489173
Tumor suppressor proteins.

LC Class. No.: QR188.6 / .T86 2022

Dewey Class. No.: 612.01575

Tumor suppressor Par-4structural features, molecular mechanisms and function /
LDR:02625nmm a2200325 a 4500 001 618750
003 DE-He213
005 20220111012920.0
006 m d
007 cr nn 008maaau
008 221103s2022 sz s 0 eng d
020 $a 9783030735722$q(electronic bk.)
020 $a 9783030735715$q(paper)
024 7 $a 10.1007/978-3-030-73572-2 $2 doi
035 $a 978-3-030-73572-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QR188.6 $b .T86 2022
072 7 $a MBGR $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MBGR $2 thema
082 0 4 $a 612.01575 $2 23
090 $a QR188.6 $b .T925 2022
245 0 0 $a Tumor suppressor Par-4 $h [electronic resource] : $b structural features, molecular mechanisms and function / $c edited by Vivek M. Rangnekar.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2022.
300 $a x, 323 p. : $b ill. (chiefly col.), digital ; $c 24 cm.
505 0 $a Discovery and Overview of Par-4 -- Par-4 in cell cycle regulation -- Conformational studies of the Par-4 C-terminal Domain -- Structural analysis of Par-4 and crystallographic analysis of the regulatory domain -- Regulation of Par-4 by Ubiquitinases -- REGULATION OF PAR-4 FUNCTION BY PHOSPHORYLATION -- Role of Par-4 in GRP78 translocation -- PAR-4 in the regulation of stem cell death and embryo development -- RASSF2 and the PAR-4 connection -- Regulation of tumor suppressor Par-4 by ceramide -- PAWR as a direct SRC-1/HOXC11 suppression target -- Index.
520 $a Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.
650 0 $a Tumor suppressor proteins. $3 489173
650 1 4 $a Biomedical Research. $3 243625
650 2 4 $a Internal Medicine. $3 273839
700 1 $a Rangnekar, Vivek. $3 918683
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-030-73572-2
950 $a Biomedical and Life Sciences (SpringerNature-11642)