國立高雄大學圖資館 |

登入

回首頁 到查詢結果 [ subject:"Regenerative Medicine and Tissue Engineering." ]

Nanotoxicology in safety assessment of nanomaterials

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nanotoxicology in safety assessment of nanomaterialsedited by Henriqueta Louro, Maria Joao Silva.
其他作者:	Louro, Henriqueta.
出版者:	Cham :Springer International Publishing :2022.
面頁冊數:	xii, 439 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Nanostructured materialsToxicology.
電子資源:	https://doi.org/10.1007/978-3-030-88071-2
ISBN:	9783030880712$q(electronic bk.)

Nanotoxicology in safety assessment of nanomaterials
Nanotoxicology in safety assessment of nanomaterials[electronic resource] /edited by Henriqueta Louro, Maria Joao Silva. - Cham :Springer International Publishing :2022. - xii, 439 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v. 13572214-8019 ;. - Advances in experimental medicine and biology ;946..

Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs' specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when using conventional toxicological approaches to assess their safety. Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their potentials. In response, the NMs definition has evolved, and nanotoxicology has developed towards new and more integrative approach methods to support regulatory and policy actions. This book provides a perspective on recent developments in the synthesis, application, and characterization of NMs and the related nanotechnologies, focusing on nanotoxicology for their accurate safety assessment early in the product development stage. The use of complex in vitro models, including multicellular systems and organoids, and "omics-based" approaches, such as transcriptomics or epigenomics, have greatly contributed to an in-depth understanding of the cellular and molecular mechanisms behind some NMs toxicity. Such mechanistic knowledge is equally addressed in this book and has set the basis for a predictive nanotoxicology approach building on adverse outcome pathways. In addition, considering the knowledge provided by the above-mentioned approaches, insights into risk assessment, standardization, and regulation of NMs are also included. Incorporating adequate nanosafety assessment early in the life-cycle of NMs will allow the implementation of the safe and sustainable-by-design paradigm enabling safety to keep pace with innovation. Chapters 10 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

ISBN: 9783030880712$q(electronic bk.)

Standard No.: 10.1007/978-3-030-88071-2doiSubjects--Topical Terms:

263041
Nanostructured materials
--Toxicology.

LC Class. No.: RA1270.N36

Dewey Class. No.: 615.9

Nanotoxicology in safety assessment of nanomaterials
LDR:03640nmm a2200325 a 4500 001 620438
003 DE-He213
005 20220518151112.0
006 m d
007 cr nn 008maaau
008 221121s2022 sz s 0 eng d
020 $a 9783030880712$q(electronic bk.)
020 $a 9783030880705$q(paper)
024 7 $a 10.1007/978-3-030-88071-2 $2 doi
035 $a 978-3-030-88071-2
040 $a GP $c GP
041 0 $a eng
050 4 $a RA1270.N36
072 7 $a MMGT $2 bicssc
072 7 $a MED000000 $2 bisacsh
072 7 $a MKGT $2 thema
082 0 4 $a 615.9 $2 23
090 $a RA1270.N36 $b N186 2022
245 0 0 $a Nanotoxicology in safety assessment of nanomaterials $h [electronic resource] / $c edited by Henriqueta Louro, Maria Joao Silva.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2022.
300 $a xii, 439 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 2214-8019 ; $v v. 1357
520 $a Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs' specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when using conventional toxicological approaches to assess their safety. Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their potentials. In response, the NMs definition has evolved, and nanotoxicology has developed towards new and more integrative approach methods to support regulatory and policy actions. This book provides a perspective on recent developments in the synthesis, application, and characterization of NMs and the related nanotechnologies, focusing on nanotoxicology for their accurate safety assessment early in the product development stage. The use of complex in vitro models, including multicellular systems and organoids, and "omics-based" approaches, such as transcriptomics or epigenomics, have greatly contributed to an in-depth understanding of the cellular and molecular mechanisms behind some NMs toxicity. Such mechanistic knowledge is equally addressed in this book and has set the basis for a predictive nanotoxicology approach building on adverse outcome pathways. In addition, considering the knowledge provided by the above-mentioned approaches, insights into risk assessment, standardization, and regulation of NMs are also included. Incorporating adequate nanosafety assessment early in the life-cycle of NMs will allow the implementation of the safe and sustainable-by-design paradigm enabling safety to keep pace with innovation. Chapters 10 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
650 0 $a Nanostructured materials $x Toxicology. $3 263041
650 1 4 $a Toxicology. $3 206218
650 2 4 $a Regenerative Medicine and Tissue Engineering. $3 913079
650 2 4 $a Nanophysics. $3 913122
650 2 4 $a Tissues. $3 391337
700 1 $a Louro, Henriqueta. $3 921137
700 1 $a Silva, Maria Joao. $3 921138
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
830 0 $a Advances in experimental medicine and biology ; $v 946. $3 557559
856 4 0 $u https://doi.org/10.1007/978-3-030-88071-2
950 $a Biomedical and Life Sciences (SpringerNature-11642)