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Dual-mode electro-photonic silicon b...

Colas, Jose Juan.

Dual-mode electro-photonic silicon biosensors

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Dual-mode electro-photonic silicon biosensorsby Jose Juan Colas.
作者:	Colas, Jose Juan.
出版者:	Cham :Springer International Publishing :2017.
面頁冊數:	xv, 149 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Biosensors.
電子資源:	http://dx.doi.org/10.1007/978-3-319-60501-2
ISBN:	9783319605012$q(electronic bk.)

Dual-mode electro-photonic silicon biosensors
Colas, Jose Juan.

Dual-mode electro-photonic silicon biosensors[electronic resource] /by Jose Juan Colas. - Cham :Springer International Publishing :2017. - xv, 149 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Fundamentals of Label-Free Biosensing -- Fabrication and Experimental Techniques -- The Electro-photonic Silicon Biosensor -- Study and Application of Electrografted Layers of Diazonium Ions -- Tailoring Light-matter Interaction for Quantiﬁcation of Biological and Molecular Layers -- Conclusions and Outlook.

This highly interdisciplinary thesis reports ontwo innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach's ability to study molecular conformation and conformational changes in real timeis demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.

ISBN: 9783319605012$q(electronic bk.)

Standard No.: 10.1007/978-3-319-60501-2doiSubjects--Topical Terms:

188824
Biosensors.

LC Class. No.: R857.B54

Dewey Class. No.: 621.381536

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520 $a This highly interdisciplinary thesis reports ontwo innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach's ability to study molecular conformation and conformational changes in real timeis demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.
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