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ERBB受體的磷酸化之數學模型 = A mathematical mod...

吳宗諭

ERBB受體的磷酸化之數學模型 = A mathematical model for the phosphorylation of ERBBreceptors

Record Type:	Language materials, printed : monographic
Paralel Title:	A mathematical model for the phosphorylation of ERBBreceptors
Author:	吳宗諭,
Secondary Intellectual Responsibility:	國立高雄大學
Place of Publication:	[高雄市]
Published:	撰者;
Year of Publication:	2008[民97]
Description:	36面圖，表 : 30公分;
Subject:	ErbB受體
Subject:	ErbB receptor
Online resource:	http://handle.ncl.edu.tw/11296/ndltd/64050238698566522432
Notes:	指導教授：陳晴玉
Notes:	參考書目：面27-28
Summary:	ErbB受體能傳遞細胞生長訊息，同時可以作為治療癌症的標的物，例如肺癌和乳癌。 ErbB受體在細胞上的活動包括dimerisation、trafficking和磷酸化/去磷酸化。我們使用常微分方程系統來描述訊息傳遞的過程。首先，我們利用多重時間維度的特性和使用擾動方法去研究一個簡單的系統。其次，我們發展一個數學模型去模擬ErbB受體的磷酸化並且證實去磷酸化主要發生在細胞內部而不是細胞表面。 ErbB receptors are the transmitters of cell proliferation signals and simultaneously can be targets of therapy for several cancers like lung and breast. The dynamic system of ErbB receptors involves dimerisation, trafficking, and phosphorylation/de-phosphorylation. A system of ordinary differential equations is present to describe the signaling process. We first exploit the characteristic of multiple timescales and study a reduced system using singular perturbation method. Secondly, we develop a mathematical model to simulate the phosphorylation of ErbB receptors and verify the hypothesis that de-phosphorylation occurs chiefly in the intracellular endosomal compartment rather than on cell surface membrane.

ERBB受體的磷酸化之數學模型 = A mathematical model for the phosphorylation of ERBBreceptors
吳, 宗諭

ERBB受體的磷酸化之數學模型 = A mathematical model for the phosphorylation of ERBBreceptors / 吳宗諭撰 - [高雄市] : 撰者, 2008[民97]. - 36面 ; 圖，表 ; 30公分.
指導教授：陳晴玉參考書目：面27-28.
ErbB受體ErbB receptor

ERBB受體的磷酸化之數學模型 = A mathematical model for the phosphorylation of ERBBreceptors
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330 $a ErbB受體能傳遞細胞生長訊息，同時可以作為治療癌症的標的物，例如肺癌和乳癌。 ErbB受體在細胞上的活動包括dimerisation、trafficking和磷酸化/去磷酸化。我們使用常微分方程系統來描述訊息傳遞的過程。首先，我們利用多重時間維度的特性和使用擾動方法去研究一個簡單的系統。其次，我們發展一個數學模型去模擬ErbB受體的磷酸化並且證實去磷酸化主要發生在細胞內部而不是細胞表面。 ErbB receptors are the transmitters of cell proliferation signals and simultaneously can be targets of therapy for several cancers like lung and breast. The dynamic system of ErbB receptors involves dimerisation, trafficking, and phosphorylation/de-phosphorylation. A system of ordinary differential equations is present to describe the signaling process. We first exploit the characteristic of multiple timescales and study a reduced system using singular perturbation method. Secondly, we develop a mathematical model to simulate the phosphorylation of ErbB receptors and verify the hypothesis that de-phosphorylation occurs chiefly in the intracellular endosomal compartment rather than on cell surface membrane.
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