國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Indole diterpenoid synthetic studies...

Davulcu, Akin H.

Indole diterpenoid synthetic studies: The total synthesis of (+)-nodulisporic acid F and studies toward the total synthesis of (-)-nodulisporic acid D.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Indole diterpenoid synthetic studies: The total synthesis of (+)-nodulisporic acid F and studies toward the total synthesis of (-)-nodulisporic acid D.
作者:	Davulcu, Akin H.
面頁冊數:	308 p.
附註:	Adviser: Amos B. Smith, III.
附註:	Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3134.
Contained By:	Dissertation Abstracts International67-06B.
標題:	Chemistry, Organic.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3223349
ISBN:	9780542738777

Indole diterpenoid synthetic studies: The total synthesis of (+)-nodulisporic acid F and studies toward the total synthesis of (-)-nodulisporic acid D.
Davulcu, Akin H.

Indole diterpenoid synthetic studies: The total synthesis of (+)-nodulisporic acid F and studies toward the total synthesis of (-)-nodulisporic acid D. - 308 p.

Adviser: Amos B. Smith, III.

Thesis (Ph.D.)--University of Pennsylvania, 2006.

*Please refer to dissertation for diagrams.

ISBN: 9780542738777Subjects--Topical Terms:

193634
Chemistry, Organic.

Indole diterpenoid synthetic studies: The total synthesis of (+)-nodulisporic acid F and studies toward the total synthesis of (-)-nodulisporic acid D.
LDR:02208nmm _2200277 _450 001 180592
005 20080111103748.5
008 090528s2006 eng d
020 $a 9780542738777
035 $a 00311617
040 $a UMI $c UMI
100 0 $a Davulcu, Akin H. $3 264168
245 1 0 $a Indole diterpenoid synthetic studies: The total synthesis of (+)-nodulisporic acid F and studies toward the total synthesis of (-)-nodulisporic acid D.
300 $a 308 p.
500 $a Adviser: Amos B. Smith, III.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3134.
502 $a Thesis (Ph.D.)--University of Pennsylvania, 2006.
520 # $a *Please refer to dissertation for diagrams.
520 # $a Chapter one of this dissertation provides a general introduction to the indole diterpenoid class of natural products, with an emphasis on the recently discovered nodulisporic acids. Chapter two describes the stereocontrolled total synthesis of (+)-nodulisporic acid F. Highlights of the modular synthetic strategy include an efficient anionic coupling via the Smith 2-substituted indole synthesis, an optimized C-ring annulation protocol, and a late-stage installation of the alpha,beta-unsaturated carboxylic acid sidechain via the B-alkyl Suzuki-Miyaura cross-coupling reaction.*
520 # $a Chapter three details our overall strategy for the convergent, asymmetric total synthesis of (-)-nodulisporic acid D, a representative member of a recently nodulisporane class of architecturally complex indole alkaloids. In addition, we describe an expedient, stereocontrolled preparation of tricyclic western hemisphere subtarget (-)-104. Successful union of (-)- 104 with eastern hemisphere subtarget (-)-125 via our 2-substituted indole synthesis has enabled construction of the heptacyclic core of (-)-nodulisporic acid D.*
590 $a School code: 0175.
650 # 0 $a Chemistry, Organic. $3 193634
690 $a 0490
710 0 # $a University of Pennsylvania. $3 212781
773 0 # $g 67-06B. $t Dissertation Abstracts International
790 $a 0175
790 1 0 $a Smith, Amos B., III, $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://libsw.nuk.edu.tw:81/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3223349 $z http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3223349