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Osteoporosis

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Osteoporosisedited by Robert Marcus ... [et al.].
其他作者:	Marcus, Robert,
出版者:	Amsterdam ;Elsevier Academic Press,c2008.
面頁冊數:	2 v. (xxv, 1941 p., [16] p. of plates) :ill. ;29 cm.
標題:	Osteoporosispathology.
電子資源:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123705440

Osteoporosis
Osteoporosis[electronic resource] /edited by Robert Marcus ... [et al.]. - 3rd ed. - Amsterdam ;Elsevier Academic Press,c2008. - 2 v. (xxv, 1941 p., [16] p. of plates) :ill. ;29 cm.

Includes bibliographical references and index.

Introduction -- The Bone Organ System: Form and Function -- The Nature of Osteoporosis -- The Economics of Osteoporosis -- Reflections on Osteoporosis -- Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the -- Understanding of Osteoporosis -- Basic Science/Bone Biology -- Osteoblast Biology -- Osteoclast Biology -- Osteocytes -- The Regulatory Role of Matrix Proteins in Mineralization of Bone -- Development of the Skeleton -- Mouse Genetics as a Tool to Study Bone Development and Physiology -- Parathyroid Hormone and Parathyroid Hormone-Related Protein -- Vitamin D: Biology, Action, and Clinical Implications -- Regulation of Bone Cell Function by Estrogens -- Androgens and Skeletal Biology: Basic Mechanisms -- Phosphatonins -- Wnt Signaling in Bone -- Cytokines and Bone Remodeling -- Skeletal Growth Factors -- Intercellular Communication During Bone Remodeling -- Structural and Biomechanics -- Skeletal Development: Mechanical Consequences of Growth, Aging and Disease -- Inhibition of Osteoporosis by Biophysical Intervention -- Biomechanics of Age-Related Fractures -- Bone Quality -- Epidemiology & Risk Factors -- Epidemiologic Methods in Studies of Osteoporosis -- Race, Ethnicity and Osteoporosis -- The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions -- Bone Mineral Acquisition in Utero and During Infancy and Childhood -- Bone Acquisition in Adolescence -- Genetic Determinants of Osteoporosis -- Nutrition and Risk for Osteoporosis -- Physical Activity in Prevention of Osteoporosis and Associated Fractures -- Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis -- Non-Skeletal Risk Factors for Osteoporosis and Fractures -- Falls as Risk Factors for Fracture -- Assessment of Fracture Risk -- Outcomes of Osteoporotic Fractures -- Pathophysiology -- Local and Systemic Factors in the Pathogenesis of Osteoporosis -- Animal Models for Osteoporosis -- Estrogen, Bone Homeostasis and Osteoporosis -- Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss -- Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization -- Osteoporosis in Childhood and Adolescence -- Glucocorticoid-Induced Osteoporosis -- Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach -- Mechanisms of Immobilization-induced Bone Loss -- Leptin-Dependent Regulation of Bone Mass -- Thyroid Hormone and the Skeleton -- Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease -- The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis -- Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis -- Osteoporosis Associated with Illnesses and Medications -- Transplantation Osteoporosis -- Osteoporosis Associated with Cancer Therapy -- Osteoporosis Associated with Pregnancy -- Osteoporosis Associated with Rheumatologic Disease -- Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks -- Localized Osteoporosis -- Evaluation and Management -- Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis -- Who Should be Screened: Who Should be Treated? -- Radiology of Osteoporosis -- Clinical Use of Bone Densitometry -- Biochemical Markers of Bone Turnover in Osteoporosis -- The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis -- An Orthopedic Perspective of Osteoporosis -- Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs -- Pharmacology and Therapeutics -- Design Considerations for Clinical Investigations of Osteoporosis -- Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials -- Evidence-Based Osteoporosis Care -- The Role of Calcium in the Treatment of Osteoporosis -- Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis -- Estrogen Therapy: Prevention and Treatment of Osteoporosis -- Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens -- Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis -- Calcitonin in Osteoporosis -- Strontium Therapy for Osteoporosis -- Androgens -- Treatment with PTH Peptides -- Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis -- New approaches to Osteoporosis Therapeutics.

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780123705440

Source: 132416:132524Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

454938
Osteoporosis
--pathology.Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RC931.O73 / O75 2008eb

Dewey Class. No.: 616.716

National Library of Medicine Call No.: 2007 L-522

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245 0 0 $a Osteoporosis $h [electronic resource] / $c edited by Robert Marcus ... [et al.].
250 $a 3rd ed.
260 $a Amsterdam ; $a Boston : $b Elsevier Academic Press, $c c2008.
300 $a 2 v. (xxv, 1941 p., [16] p. of plates) : $b ill. ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a Introduction -- The Bone Organ System: Form and Function -- The Nature of Osteoporosis -- The Economics of Osteoporosis -- Reflections on Osteoporosis -- Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the -- Understanding of Osteoporosis -- Basic Science/Bone Biology -- Osteoblast Biology -- Osteoclast Biology -- Osteocytes -- The Regulatory Role of Matrix Proteins in Mineralization of Bone -- Development of the Skeleton -- Mouse Genetics as a Tool to Study Bone Development and Physiology -- Parathyroid Hormone and Parathyroid Hormone-Related Protein -- Vitamin D: Biology, Action, and Clinical Implications -- Regulation of Bone Cell Function by Estrogens -- Androgens and Skeletal Biology: Basic Mechanisms -- Phosphatonins -- Wnt Signaling in Bone -- Cytokines and Bone Remodeling -- Skeletal Growth Factors -- Intercellular Communication During Bone Remodeling -- Structural and Biomechanics -- Skeletal Development: Mechanical Consequences of Growth, Aging and Disease -- Inhibition of Osteoporosis by Biophysical Intervention -- Biomechanics of Age-Related Fractures -- Bone Quality -- Epidemiology & Risk Factors -- Epidemiologic Methods in Studies of Osteoporosis -- Race, Ethnicity and Osteoporosis -- The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions -- Bone Mineral Acquisition in Utero and During Infancy and Childhood -- Bone Acquisition in Adolescence -- Genetic Determinants of Osteoporosis -- Nutrition and Risk for Osteoporosis -- Physical Activity in Prevention of Osteoporosis and Associated Fractures -- Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis -- Non-Skeletal Risk Factors for Osteoporosis and Fractures -- Falls as Risk Factors for Fracture -- Assessment of Fracture Risk -- Outcomes of Osteoporotic Fractures -- Pathophysiology -- Local and Systemic Factors in the Pathogenesis of Osteoporosis -- Animal Models for Osteoporosis -- Estrogen, Bone Homeostasis and Osteoporosis -- Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss -- Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization -- Osteoporosis in Childhood and Adolescence -- Glucocorticoid-Induced Osteoporosis -- Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach -- Mechanisms of Immobilization-induced Bone Loss -- Leptin-Dependent Regulation of Bone Mass -- Thyroid Hormone and the Skeleton -- Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease -- The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis -- Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis -- Osteoporosis Associated with Illnesses and Medications -- Transplantation Osteoporosis -- Osteoporosis Associated with Cancer Therapy -- Osteoporosis Associated with Pregnancy -- Osteoporosis Associated with Rheumatologic Disease -- Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks -- Localized Osteoporosis -- Evaluation and Management -- Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis -- Who Should be Screened: Who Should be Treated? -- Radiology of Osteoporosis -- Clinical Use of Bone Densitometry -- Biochemical Markers of Bone Turnover in Osteoporosis -- The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis -- An Orthopedic Perspective of Osteoporosis -- Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs -- Pharmacology and Therapeutics -- Design Considerations for Clinical Investigations of Osteoporosis -- Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials -- Evidence-Based Osteoporosis Care -- The Role of Calcium in the Treatment of Osteoporosis -- Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis -- Estrogen Therapy: Prevention and Treatment of Osteoporosis -- Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens -- Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis -- Calcitonin in Osteoporosis -- Strontium Therapy for Osteoporosis -- Androgens -- Treatment with PTH Peptides -- Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis -- New approaches to Osteoporosis Therapeutics.
505 0 $a The bone organ system: form and function -- The nature of osteporosis -- The economics of osteoporosis -- Reflections on osteoporosis -- Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteporosis -- Osteoblast biology -- Osteoclast biology -- Osteocytes -- The regulatory role of matrix proteins in mineralization of bone -- Development of the skeleton -- Mouse genetics as a tool to study bone development and physiology -- Parathyroid hormone and parathyroid hormone-related protein -- Vitamin D: biology, action, and clinical implications -- Regulation of bone cell function by estrogens -- Androgens and skeletal biology: basic mechanisms -- Phosphatonins -- Wnt Signaling in bone -- Cytokins and bone remodeling -- Skeletal growth factors -- Intercellular communication during bone remodeling -- Skeletal development: mechanical consequences of growth, aging, and disease -- Inhibition of osteoporosis by biophysical intervention -- Biomechanics of age-related fractures -- Bone quality -- Epidemiologic methods in studies of osteoporosis -- Race, ethnicity and osteoporosis -- The study of osteoporotic fractures: major findings and contributions -- Bone mineral acquistion In Utero and during infancy and childhood -- Bone acquisition in adolescence -- Genetic determinants of osteoporosis -- Nutrition and risk for osteoporosis -- Physical activity in prevention of osteoporosis and associated fractures -- Premenopausal reproductive and hormonal characteristics and the risk for osteoporosis -- Nonskeletal risk factors for osteoporosis and fractures -- Falls as risk factors for fracture -- Assessment of fracture risk -- Outcomes of osteoporotic fractures -- Local and systemic factors in the pathogenesis of osteoporosis -- Animal modesl for osteoporosis -- Estrogen, bone homeostasis, and osteoporosis -- Postmenopausal osteoporosis: how the hormonal changes of menopause cause bone loss -- Osteoporosis in men: epidemiology, pathophysiology, and clinical characterization -- Osteoporosis in childhood and adolescence --
505 0 $a Glucocorticoid-induced osteoporosis -- Adult scoliosis, degenerative disease, and BMD: a subsegmental analytic approach -- Mechanisms of immobilization-induced bone loss -- Leptin-dependent regulation of bone mass -- Thyroid hormone and the skeleton -- Osteoporosis in gastrointestinal, pancreatic, and hepatic diseases -- The skeletal actions of parathyroid hormone in primary hyperparathyroidism and in osteoporosis -- Osteogenesis imperfecta and other defects of bone development as occasional causes of adult osteoporosis -- Osteoporosis associated with illnesses and medications -- Transplantation osteoporosis -- Osteoporosis associated with cancer therapy -- Osteoporosis associated with pregnancy -- Osteoporosis associated with rheumatologic disorders -- Oral bone loss and systemic osteopenia: potential treatment and risks -- Localized osteoporosis -- Evaluation of the patient with osteoporosis or at risk for osteoporosis -- Who should be screened: who should be treated? -- Radiology of osteoporosis -- Clinical use of bone densitometry -- Biochemical markers of bone turnover in osteoporosis -- The conundrum of compliance and persistence with oral biophosphonates for postmenopausal osteoporosis -- An orthopedic perspective of osteoporosis -- Lessons from the bone histomorphometry on the mechanism of action of osteoporosis drugs -- Design considerations for clinical investigations of osteoporosis -- Regulatory considerations for the design and conduct of osteoporosis registration trials -- Evidence-based osteoporosis care -- The role of calcium in the treatment of osteoporosis -- Vitamin D and its metabolites and analogs in the management of osteoporosis -- Estrogen therapy: prevention and treatment of osteoporosis -- Estrogen analogues: selective estrogen receptor modulators and phytoestrogens -- Bisphosphonates: pharmacology and use in the treatment of osteoporosis -- Calcitonin in osteoporosis -- Strontium ranelate -- Androgens -- Treatment with PTH peptides -- Growth hormone and insulin-like growth factors: potential applications and limitations in the management of osteoporosis -- New approaches to osteoporosis therapeutics.
520 $a Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $1 8 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2008. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on May 14, 2008). $n Access may be restricted to users at subscribing institutions.
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