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模擬G蛋白偶聯受體之調節:原發性內移作用與受配體誘發的內吞作用 = Mo...

國立高雄大學應用數學系碩士班

模擬G蛋白偶聯受體之調節:原發性內移作用與受配體誘發的內吞作用 = Modelling the regulation of G-protein coupled receptors:Constitutive internalization and ligand-induced endocytosis

Record Type:	Language materials, printed : monographic
Paralel Title:	Modelling the regulation of G-protein coupled receptors:Constitutive internalization and ligand-induced endocytosis
Author:	李菊雅,
Secondary Intellectual Responsibility:	國立高雄大學
Place of Publication:	[高雄市]
Published:	撰者;
Year of Publication:	民99[2010]
Description:	42面圖，表 : 30公分;
Subject:	G蛋白偶聯受體
Subject:	G-protein coupled receptors
Online resource:	http://handle.ncl.edu.tw/11296/ndltd/37219368813842642538
Summary:	在這裡我們用常微分方程系統來模擬G 蛋白偶聯受體之調節路徑 - 受配體誘發的內吞作用,觀察G 蛋白偶聯受體受配體刺激而誘發細胞反應的同時其濃度之變化.我們藉由多重時間維度的特性使用擾動方法表現其模擬結果,並以數值計算方式佐證其結果之精確性；同時討論配體與受體在不同濃度比例下其反應行為之差異.最後,延伸考慮G 蛋白偶聯受體在未受配體誘發亦會產生原發性內移作用.此模擬系統說明了G 蛋白偶聯受體之調節反應無論受配體誘發與否皆可達到穩定狀態. A system of nonlinear ordinary differential equations is used to describe the regulation of G protein-coupled receptors. In particular, we consider the effect of ligand-induced endocytosis on the receptor concentration. The resulting system exhibits the characteristics of multiple time scales. We first simulate the results numerically and later, use singular perturbation technique to derive asymptotic solutions to validate the numerical results. This model is further extended to include other factors that are involved in the regulation process such as receptor synthesis and constitutive internalization of receptors in the absence of any ligand.

模擬G蛋白偶聯受體之調節:原發性內移作用與受配體誘發的內吞作用 = Modelling the regulation of G-protein coupled receptors:Constitutive internalization and ligand-induced endocytosis
李, 菊雅

模擬G蛋白偶聯受體之調節:原發性內移作用與受配體誘發的內吞作用 = Modelling the regulation of G-protein coupled receptors:Constitutive internalization and ligand-induced endocytosis / 李菊雅撰 - [高雄市] : 撰者, 民99[2010]. - 42面 ; 圖，表 ; 30公分.
參考書目：面.
G蛋白偶聯受體G-protein coupled receptors

模擬G蛋白偶聯受體之調節:原發性內移作用與受配體誘發的內吞作用 = Modelling the regulation of G-protein coupled receptors:Constitutive internalization and ligand-induced endocytosis
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330 $a 在這裡我們用常微分方程系統來模擬G 蛋白偶聯受體之調節路徑 - 受配體誘發的內吞作用,觀察G 蛋白偶聯受體受配體刺激而誘發細胞反應的同時其濃度之變化.我們藉由多重時間維度的特性使用擾動方法表現其模擬結果,並以數值計算方式佐證其結果之精確性；同時討論配體與受體在不同濃度比例下其反應行為之差異.最後,延伸考慮G 蛋白偶聯受體在未受配體誘發亦會產生原發性內移作用.此模擬系統說明了G 蛋白偶聯受體之調節反應無論受配體誘發與否皆可達到穩定狀態. A system of nonlinear ordinary differential equations is used to describe the regulation of G protein-coupled receptors. In particular, we consider the effect of ligand-induced endocytosis on the receptor concentration. The resulting system exhibits the characteristics of multiple time scales. We first simulate the results numerically and later, use singular perturbation technique to derive asymptotic solutions to validate the numerical results. This model is further extended to include other factors that are involved in the regulation process such as receptor synthesis and constitutive internalization of receptors in the absence of any ligand.
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