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Molecular neurology

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Molecular neurologyedited by Stephen G. Waxman.
其他作者:	Waxman, Stephen G.
出版者:	Burlington, MA :Elsevier Academic Press,c2007.
面頁冊數:	ix, 584 p. :ill. ;29 cm.
標題:	Nervous System Diseasesgenetics.
電子資源:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123695093

Molecular neurology
Molecular neurology[electronic resource] /edited by Stephen G. Waxman. - Burlington, MA :Elsevier Academic Press,c2007. - ix, 584 p. :ill. ;29 cm.

Includes bibliographical references and index.

PREFACE Stephen G. Waxman -- Section I. Principles of Molecular Neurology. -- Genetics as a Tool in Neurology. -- Neurology and Genomic Medicine. -- Mitochondrial Function and Dysfunction in the Nervous System. -- Neuronal Channels and Receptors. -- Protein Misfolding, Chaperone Networks, and the Heat Shock Response -- in the Nervous System. -- Metabolic Biopsy of the Brain. -- Gene therapy approaches in neurology. -- Programmed Cell Death and its Role in Neurological Disease. -- Section II. Disorders of Development. -- Developmental Neurology: A Molecular Perspective. -- Metabolic Diseases of the Nervous System. -- Genetic Disorders of Neuromuscular Development. -- Section III. Stroke and Trauma. -- Molecular Mechanisms of Ischemic Brain Disease. -- Hemorrhagic Brain Disease. -- The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury. -- Section IV. Degenerative Diseases. -- Parkinsons Disease: Molecular Insights. -- The molecular basis of Alzheimers disease. -- Polyglutamine Disorders including Huntingtons Disease. -- Friedreichs Ataxia and Related RNA Loss-Of-Function Disorders. -- DYT1, a Primary Torsion Dystonia. -- Motor Neuron Disease: Amyotrophic Lateral Sclerosis. -- Genetic Disorders of the Autonomic Nervous System. -- Multiple sclerosis as a neurodegenerative disease. -- Section V. Disorders of Excitation and Transmission. -- Acquired Epilepsy: Cellular and Molecular Mechanisms. -- Genetic Epilepsies. -- Tourettes Syndrome. -- Section VI. Disorders of Sleep and Circadian Rhythms. -- Disorders of Sleep and Circadian Rhythms. -- Section VII. Pain -- Cronic pain as a molecular disorder. -- Migraine as a cerebral ionopathy with impaired central sensory processing. -- Section VIII. Peripheral Nerve Disease. -- Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies. -- Section IX. Neuro-Immunology. -- Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis. -- Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal. -- Paraneoplastic Neurologic Syndromes. -- Mitochondrial Disorders. -- Section X. Infectious Disorders. -- Molecular Neurology of HIV-1 Infection and AIDs.

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. * Describes the newest, molecular aspects of neurological disorders * Provides an introduction to neurological disorders for basic scientists * Updates clinicians and clinical researchers on the most recent developments.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780123695093

Source: 115918:116016Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

301467
Nervous System Diseases
--genetics.Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RC347 / .M647 2007eb

Dewey Class. No.: 573.84

National Library of Medicine Call No.: 2007 J-007

Molecular neurology
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245 0 0 $a Molecular neurology $h [electronic resource] / $c edited by Stephen G. Waxman.
260 $a Burlington, MA : $b Elsevier Academic Press, $c c2007.
300 $a ix, 584 p. : $b ill. ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a PREFACE Stephen G. Waxman -- Section I. Principles of Molecular Neurology. -- Genetics as a Tool in Neurology. -- Neurology and Genomic Medicine. -- Mitochondrial Function and Dysfunction in the Nervous System. -- Neuronal Channels and Receptors. -- Protein Misfolding, Chaperone Networks, and the Heat Shock Response -- in the Nervous System. -- Metabolic Biopsy of the Brain. -- Gene therapy approaches in neurology. -- Programmed Cell Death and its Role in Neurological Disease. -- Section II. Disorders of Development. -- Developmental Neurology: A Molecular Perspective. -- Metabolic Diseases of the Nervous System. -- Genetic Disorders of Neuromuscular Development. -- Section III. Stroke and Trauma. -- Molecular Mechanisms of Ischemic Brain Disease. -- Hemorrhagic Brain Disease. -- The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury. -- Section IV. Degenerative Diseases. -- Parkinsons Disease: Molecular Insights. -- The molecular basis of Alzheimers disease. -- Polyglutamine Disorders including Huntingtons Disease. -- Friedreichs Ataxia and Related RNA Loss-Of-Function Disorders. -- DYT1, a Primary Torsion Dystonia. -- Motor Neuron Disease: Amyotrophic Lateral Sclerosis. -- Genetic Disorders of the Autonomic Nervous System. -- Multiple sclerosis as a neurodegenerative disease. -- Section V. Disorders of Excitation and Transmission. -- Acquired Epilepsy: Cellular and Molecular Mechanisms. -- Genetic Epilepsies. -- Tourettes Syndrome. -- Section VI. Disorders of Sleep and Circadian Rhythms. -- Disorders of Sleep and Circadian Rhythms. -- Section VII. Pain -- Cronic pain as a molecular disorder. -- Migraine as a cerebral ionopathy with impaired central sensory processing. -- Section VIII. Peripheral Nerve Disease. -- Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies. -- Section IX. Neuro-Immunology. -- Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis. -- Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal. -- Paraneoplastic Neurologic Syndromes. -- Mitochondrial Disorders. -- Section X. Infectious Disorders. -- Molecular Neurology of HIV-1 Infection and AIDs.
505 0 $a Genetics as a tool in neurology -- Neurology and genomic medicine -- Mitochondrial function and dysfunction in the nervous system -- Neuronal channels and receptors -- Protein misfolding, chaperone networks, and the heat shock response in the nervous system -- Metabolic biopsy of the brain -- Gene therapy approaches in neurology -- Programmed cell death and its role in neurological disease -- Developmental neurology: a molecular perspective -- Metabolic diseases of the nervous sytsem -- Genetic disorders of neuromuscular development -- Molecular mechanisms of ischemic brain disease -- Hemorrhagic brain disease -- The Dawn of molecular and cellular therapies for traumatic spinal cord injury -- Parkinson disease: molecular insights -- The Molecular basis of Alzheimer's disease -- Polyglutamine disorders including Huntington's disease -- Friedreich's ataxia and related DNA loss-of-function disorders -- DYT1, an inherited dystonia --
505 0 $a Motor neuron disease: amyotrophic lateral sclerosis -- Genetic disorders of the autonomic nervous system -- Multiple sclerosis as a neurodegenerative disease -- Acquired epilepsy: cellular and molecular mechanisms -- Genetic epilepsies -- Tourette's syndrome -- Disorders of sleep and circadian rhythms -- Chronic pain as a molecular disorder -- Migraine as a cerebral ionopathy with impaired central sensory processing -- Myelin protein zero and CMT 1 B: a tale of two phenotypes -- Demyelinating diseases: immunological mechanisms in the pathogenesis of multiple sclerosis -- Autoimmune and genetic disorders of the neuromuscular junction and motor nerve terminal -- Paraneoplastic neurologic syndromes -- Mitochondrial disorders -- Molecular neurology of HIV-1 infection and AIDS.
520 $a Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. * Describes the newest, molecular aspects of neurological disorders * Provides an introduction to neurological disorders for basic scientists * Updates clinicians and clinical researchers on the most recent developments.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2008. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on May 14, 2008). $n Access may be restricted to users at subscribing institutions.
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700 1 $a Waxman, Stephen G. $3 393179
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856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123695093 $z An electronic book accessible through the World Wide Web; click for information
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