國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Quasispeciesfrom theory to experimen...

Domingo, Esteban.

Quasispeciesfrom theory to experimental systems /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Quasispeciesedited by Esteban Domingo, Peter Schuster.
其他題名:	from theory to experimental systems /
其他作者:	Domingo, Esteban.
出版者:	Cham :Springer International Publishing :2016.
面頁冊數:	xiv, 357 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Virology.
電子資源:	http://dx.doi.org/10.1007/978-3-319-23898-2
ISBN:	9783319238982$q(electronic bk.)

Quasispeciesfrom theory to experimental systems /
Quasispeciesfrom theory to experimental systems /[electronic resource] :edited by Esteban Domingo, Peter Schuster. - Cham :Springer International Publishing :2016. - xiv, 357 p. :ill., digital ;24 cm. - Current topics in microbiology and immunology,v.3920070-217X ;. - Current topics in microbiology and immunology ;v.351..

What is a quasispecies?- Historical origins and current scope -- The nucleation of semantic information in prebiotic matter -- Evolution of RNA-based networks -- Quasispecies on fitness landscapes -- Mathematical models of quasispecies theory and exact results for the dynamics -- Theoretical Models of Generalized Quasispecies -- Theories of lethal mutagenesis: from error catastrophe to lethal defection -- Estimating fitness of viral quasispecies from next-generation sequencing data -- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models -- Cooperative Interaction within RNA Virus Mutant Spectra -- Arenavirus Quasispecies And Their Biological Implications -- Models of viral population dynamics -- Fidelity variants and RNA quasispecies -- Antiviral strategies based on lethal mutagenesis and error threshold.

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

ISBN: 9783319238982$q(electronic bk.)

Standard No.: 10.1007/978-3-319-23898-2doiSubjects--Topical Terms:

196498
Virology.

LC Class. No.: QR360

Dewey Class. No.: 579.2

Quasispeciesfrom theory to experimental systems /
LDR:02897nmm a2200325 a 4500 001 483706
003 DE-He213
005 20160908161838.0
006 m d
007 cr nn 008maaau
008 161012s2016 gw s 0 eng d
020 $a 9783319238982$q(electronic bk.)
020 $a 9783319238975$q(paper)
024 7 $a 10.1007/978-3-319-23898-2 $2 doi
035 $a 978-3-319-23898-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QR360
072 7 $a MMFM $2 bicssc
072 7 $a MED052000 $2 bisacsh
082 0 4 $a 579.2 $2 23
090 $a QR360 $b .Q1 2016
245 0 0 $a Quasispecies $h [electronic resource] : $b from theory to experimental systems / $c edited by Esteban Domingo, Peter Schuster.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a xiv, 357 p. : $b ill., digital ; $c 24 cm.
490 1 $a Current topics in microbiology and immunology, $x 0070-217X ; $v v.392
505 0 $a What is a quasispecies?- Historical origins and current scope -- The nucleation of semantic information in prebiotic matter -- Evolution of RNA-based networks -- Quasispecies on fitness landscapes -- Mathematical models of quasispecies theory and exact results for the dynamics -- Theoretical Models of Generalized Quasispecies -- Theories of lethal mutagenesis: from error catastrophe to lethal defection -- Estimating fitness of viral quasispecies from next-generation sequencing data -- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models -- Cooperative Interaction within RNA Virus Mutant Spectra -- Arenavirus Quasispecies And Their Biological Implications -- Models of viral population dynamics -- Fidelity variants and RNA quasispecies -- Antiviral strategies based on lethal mutagenesis and error threshold.
520 $a This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.
650 0 $a Virology. $3 196498
650 0 $a RNA viruses. $3 506011
650 0 $a Species. $3 489210
650 1 4 $a Biomedicine. $3 273648
650 2 4 $a Human Genetics. $3 273658
650 2 4 $a Immunology. $3 189152
700 1 $a Domingo, Esteban. $3 259283
700 1 $a Schuster, Peter. $3 275273
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Current topics in microbiology and immunology ; $v v.351. $3 557512
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-23898-2
950 $a Biomedical and Life Sciences (Springer-11642)